Thromb Haemost 2004; 91(02): 360-366
DOI: 10.1160/TH03-04-0256
Platelets and Blood Cells
Schattauer GmbH

Relationships between plasma adiponectin and blood cells, hepatopancreatic enzymes in women

Miyao Matsubara
1   Division of Endocrinology and Metabolism, Otaru City General Hospital, Otaru, Japan
,
Katsuhiko Namioka
2   Laboratory Medicine, Otaru City General Hospital, Otaru, Japan
,
Shinji Katayose
3   Otsuka Assay Institute, Sapporo, Japan
› Author Affiliations

Grant support: This work was supported in part by a grant from the Tanita Health Body Weight Foundation in Japan.
Further Information

Publication History

Received 30 April 2003

Accepted after resubmission 11 January 2003

Publication Date:
01 December 2017 (online)

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Summary

Adiponectin, which is secreted specifically from adipocyte, is thought to play a key role in the metabolic syndrome. We studied the associations of plasma adiponectin concentrations with blood cells and hepatopancreatic enzymes in 339 women aged 54.0 ± 0.8 (mean ± SE) years. Plasma adiponectin before and after adjustment for body composition or calculated insulin resistance increased in slight anemic women (372.6 ± 2.6 ×104/mm3) compared with non-anemic subjects (471.1 ± 1.7) (all p < 0.0001), and were inversely associated with red blood cells (RBC), hemoglobin, hematocrit, white blood cells and platelet values (p < 0.0001 ∼ 0.02), independent of age, diastolic blood pressure, body mass index, serum triglyceride, insulin resistance or blood urea nitrogen. Age and adiponectin/body fat mass (%) were negative, and blood pressure and insulin resistance were positive significant independent determinants of RBC in stepwise regression analysis. Moreover, adiponectin before and after adjustment were inversely associated with serum ALAT,γGTP and ChE, and positively with amylase levels (p < 0.0001 ∼ 0.02). These results indicate the possibility that increased adiponectin may contribute to the suppressive bone marrow function in vivo. Combined with the leptin’s data, adipocyte derived proteins were related to the hematopoiesis, therefore it has shown the possible existence of adipose tissue/ bone marrow function linkage more clearly. Furthermore, hepatopancreatic enzyme associations with this protein may indicate the possibility that adiponectin will regulate the hepatopancreatic function in health and disease.