Neuropsycho-Cardiologic Risks Associated with Menopausal Women – Benefits of a Plant Based Formulation

The anatomic, physiologic alterations in the ovary that eventually result in diminished estrogen production begin several years before permanent cessation of menstruation among the women. The relationship between menopause and cardiovascular risk is established and it is well documented that estrogen depletion is responsible for cardiovascular risk. A double blind placebo controlled study was carried out with the object to minimize the neuro-psycho-cardiologic risks associated with menopausal women by a plant based formulation containing the organic extract of Dioscorea bulbifera and Hippophae rhamnoides in effective doses. After determination of safety and efficacy profile in various animal studies, the drug was slated for human trials. The beneficial role of the test drug was validated on coronary heart disease (CHD) risk biomarkers particularly lipid profile, homocysteine, C-reactive Protein, Interleukin-6, along with anxiety and depression among 65 menopausal women. A group of 38 menopausal women were kept on placebo therapy to compare results. It is observed that the novel test formulation has potential effect in reducing the elevated plasma homocysteine, C-reactive protein and Interleukin-levels. It also regulated the abnormal lipid levels, and thus, the future incidence of atherosclerotic vascular disease can be prevented among menopausal women without any adverse effect.