Exp Clin Endocrinol Diabetes 2010; 118(3): 184-189
DOI: 10.1055/s-2008-1081499
Article

© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Vaspin (SERPINA12) Genotypes and Risk of Type 2 Diabetes: Results from the MONICA/KORA studies

K. Kempf 1 [*] , B. Rose 1 [*] , T. Illig 2 [*] , W. Rathmann 3 , K. Strassburger 3 , B. Thorand 2 , C. Meisinger 2 , H.-E. Wichmann 2 , 4 , C. Herder 1 , C. Vollmert 2
  • 1Institute for Clinical Diabetes Research, German Diabetes Centre, Leibniz Institute for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany
  • 2Institute of Epidemiology, Helmholtz Zentrum München – German Research Centre for Environmental Health, Neuherberg, Germany
  • 3Institute of Biometrics and Epidemiology, German Diabetes Centre, Leibniz Institute for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany
  • 4IBE, Chair of Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany
Further Information

Publication History

received 29.02.2008 first decision 16.04.2008

accepted 19.06.2008

Publication Date:
25 August 2008 (online)

Abstract

Vaspin has recently been identified as novel adipokine with high expression in adipose tissue of obese and type 2 diabetic subjects and with potentially insulin-sensitising properties. However, the impact of vaspin gene variants on the risk of type 2 diabetes mellitus (T2DM) has not been determined yet. Therefore, the aim of our study was to investigate the association of vaspin single nucleotide polymorphisms (SNPs) with T2DM and obesity. We analysed the association between 25 vaspin SNPs and T2DM in initially healthy 35–84 year-old individuals of the population-based, cross-sectional German KORA F3 study and assessed the association with measures of obesity. Genotyping was carried out with matrix-assisted laser desorption/ionisation-time of flight mass spectrometry of allele-dependent primer extension products and associations with T2DM and obesity were analysed by logistic regression analysis. Our results demonstrate a significant association of vaspin SNP rs2236242 with T2DM in the KORA F3 study with the AA genotype bearing an increased risk (adjusted OR 2.35 [1.59; 3.46] versus AT/TT). This association appears to be independent of obesity. Our finding corroborates previous studies that suggested a link between the novel adipokine vaspin and glucose metabolism.

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1 These authors contributed equally to the work.

Correspondence

Dr. C. Herder

Institute for Clinical Diabetes Research

German Diabetes Centre

Leibniz Institute for Diabetes Research at Heinrich-Heine-University Düsseldorf

Auf'm Hennekamp 65

40225 Düsseldorf

Germany

Phone: +49/211/3382 647

Fax: +49/211/3382 603

Email: Christian.Herder@ddz.uni-duesseldorf.de