Planta Med 2008; 74(11): 1412-1415
DOI: 10.1055/s-2008-1081318
Natural Products Chemistry
Letter
© Georg Thieme Verlag KG Stuttgart · New York

Triterpenoid Saponins with Anti-Inflammatory Activity from Codonopsis lanceolata

Li-Ping Xu1 , Hao Wang2 , Zhong Yuan1
  • 1School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, P. R. China
  • 2The First Clinical Hospital, Jilin University, Changchun, P. R. China
Further Information

Publication History

Received: April 21, 2008 Revised: June 3, 2008

Accepted: June 6, 2008

Publication Date:
29 July 2008 (online)

Abstract

Six triterpenoid saponins, including a new compound named codonolaside III, were isolated from the roots of Codonopsis lanceolata. The spectral and chemical data revealed the structure of codonolaside III to be 3-O-[β-D-xylopyranosyl -(1→3)-β-D-glucuronopyranosyl]-3β,16α-dihydroxyolean-12-ene-28-oic acid 28-O-[β-D-xylopyranosyl-(1→4)-α-L-rhamnpyranosyl-(1→2)][β-D-glucopyranosyl -(1→4)]-α-L-arabinopyranosyl ester. The xylene-induced mouse ear edema inhibitory effect assay disclosed codonolaside and codonolasides I – III as the major anti-inflammatory constituents in this crude drug.

References

Dr. Zhong Yuan

Department of Analysis of Traditional Chinese Medicine

School of Traditional Chinese Materia Medica

Shenyang Pharmaceutical University

Shenyang 110016

People's Republic of China

Phone: +86-024-2398-6469

Email: yuanzhong@syphu.edu.cn

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