Planta Med 2008; 74(11): 1405-1408
DOI: 10.1055/s-2008-1081301
Natural Products Chemistry
Letter
© Georg Thieme Verlag KG Stuttgart · New York

In vitro BACE-1 Inhibitory Phenolic Components from the Seeds of Psoralea corylifolia

Yeon Hee Choi1 , Gyu Hwan Yon1 , Kyung Sik Hong1 , Dae Seok Yoo1 , Chun Whan Choi1 , Woo-Kyu Park1 , Jae Yang Kong1 , Young Sup Kim1 , Shi Yong Ryu1
  • 1Korea Research Institute of Chemical Technology, Daejeon, Korea
Further Information

Publication History

Received: March 11, 2008 Revised: May 26, 2008

Accepted: May 28, 2008

Publication Date:
29 July 2008 (online)

Abstract

A new isoflavone, neocorylin (1) was isolated from the seeds extract of Psoralea corylifolia L. (Fabaceae), together with eight known constituents (2 – 9), i. e., bakuchiol (2), psoralen (3), bavachromene (4), isobavachromene (5), bavachalcone (6), isobavachalcone (7), 7,8-dihydro-8-(4-hydrophenyl)-2,2-dimethyl-2H,6H-[1,2-b:5,4-b′]dipyran-6-one (8), and bavachinin (9). The structure of the new isoflavone 1 was elucidated as 7-hydroxy-3-[2-methyl-2-(4-methylpenten-3-yl)-2H-chromen-6-yl]-4H-chromen-4-one by spectroscopic analyses. Neocorylin (1) as well as related compounds 2, 4 – 6, 8 and 9 exhibited a significant inhibitory effect on baculovirus-expressed BACE-1 in vitro.

References

Dr. Shi Yong Ryu

Korea Reseach Institute of Chemical Technology

Yusung

P.O. Box 107

Daejeon 305–343

Korea

Phone: +82-42-860-7163

Fax: +82-42-861-0307

Email: syryu@krict.re.kr