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Semin Musculoskelet Radiol 1999; 3(2): 101-113
DOI: 10.1055/s-2008-1080055
© 1999 by Thieme Medical Publishers, Inc.

Dynamic Contrast-Enhanced MR Imaging for Soft Tissue Sarcomas

Lorraine G. Shapeero1 , Daniel Vanel2 , Koenraad L. Verstraete3 , Johan L. Bloem4
  • 1Department of Radiology, Uniformed Services University of the Health Sciences, Bethesda, Maryland, and Department of Radiology, Walter Reed Army Medical Center, Washington, District of Columbia
  • 2Department of Radiology, Institut Gustave Roussy, Villejuif, France
  • 3Department of Radiology, University Hospital, Gent, Belgium
  • 4Department of Radiology, University Hospital, Leiden, The Netherlands
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Publication Date:
18 June 2008 (online)

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ABSTRACT

Dynamic contrast-enhanced magnetic resonance imaging has recently emerged as an important method for evaluating soft tissue sarcomas for biopsy localization, chemotherapeutic response, and long-term follow-up because of its ability to detect viable tumor. This article presents the basic principles of contrast kinetics in soft tissue sarcomas after bolus injection of contrast agent and discusses the current postprocessing methods (subtraction, first-pass image and time-intensity curves with region of interest, and color-encoded techniques) used to display these dynamic studies. Because of its excellent temporal resolution, dynamic MR imaging can delineate the early uptake of contrast agent in sarcomas within seconds after injection, almost synchronous with arterial enhancement, and thereby differentiate the rapidly enhancing viable tumor from the nonenhancing necrotic tumor and the late enhancing changes after surgery, radiation therapy, and chemotherapy.

KEYWORDS

Sarcoma, soft tissue - magnetic resonance (MR), rapid imaging - soft tissues, neoplasms - soft tissues, MR - soft tissue sarcoma, chemotherapy - soft tissue sarcoma, recurrences - soft tissue sarcoma, metastases

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