Fe-Catalyzed Cross-Coupling of Dienol Phosphates with Grignard Reagents

Significance

Iron-catalyzed cross-coupling reactions have recently attracted a great amount of attention of synthetic chemists. Herein, the authors elegantly used dienol phosphates instead of poorly stable dienyl halides as electrophiles for a simple and general Fe-catalyzed cross-coupling reaction with Grignard reagents. The reaction with alkylmagnesium salts proceeds stereoselectively and in high yields. This methodology is illustrated by a synthesis of Diparopis castanea pheromone.