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Synfacts 2008(8): 0788-0788  
DOI: 10.1055/s-2008-1077895
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of Aigialomycin D

Contributor(s): Philip Kocienski, Stewart Eccles
C. C. Chrovian, B. Knapp-Reed, J. Montgomery*
University of Michigan, Ann ARbor, USA
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Publication History

Publication Date:
23 July 2008 (online)

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Significance

Aigialomycin D was isolated from the marine mangrove fungus Aigialus parvus. It exhibits activity as an antimalarial and cytotoxic agent. This synthesis of aigialomycin D utilizes a nickel(0)-catalyzed ynal coupling to form the macrocycle.