ABSTRACT
Polycystic ovary syndrome (PCOS) is a heterogeneous endocrine disorder. The criteria
used to establish the diagnosis remain controversial. The 1990 National Institutes
of Health conference guidelines required a combination of both chronic anovulation
and clinical/or biochemical signs of hyperandrogenism. These criteria were revised
in 2003 at the Rotterdam European Society of Human Reproduction and Embryology/American
Society of Reproductive Medicine consensus workshop to include ultrasound polycystic
ovarian morphology (PCOM) as one of the two of three criteria necessary for establishing
the diagnosis of PCOS. The inclusion of PCOM sparked a controversy as it broadens
the population of women who meet the criteria for PCOS and allows for the creation
of two phenotypically different patient populations who previously would have been
excluded. The ultrasound findings, which are consistent with PCOM, include an assessment
of follicle number and/or ovarian volume. As technology advances with two-dimensional
and three-dimensional ultrasound, our ability to discretely evaluate independent portions
of the ovary may help to redefine the criteria of PCOM and thus standardize for clinical
and research interests a more specific descriptor for PCOM.
KEYWORDS
PCOS - ultrasound - Rotterdam - ovarian stroma - polycystic ovarian morphology - PCO
- PCOM
REFERENCES
1
Azziz R, Woods K S, Reyna R, Key T J, Knochenhauer E S, Yildiz B O.
The prevalence and features of the polycystic ovary syndrome in an unselected population.
J Clin Endocrinol Metab.
2004;
89
2745-2749
2
Stein I, Leventhal M.
Amenorrhoea associated with bilateral polycystic ovaries.
Am J Obstet Gynecol.
1935;
29
181-185
3
Rebar R, Judd H L, Yen S S, Rakoff J, Vandenberg G, Naftolin F.
Characterization of the inappropriate gonadotropin secretion in polycystic ovary syndrome.
J Clin Invest.
1976;
57
1320-1329
4
Kalro B N, Loucks T L, Berga S L.
Neuromodulation in polycystic ovary syndrome.
Obstet Gynecol Clin North Am.
2001;
28
35-62
5
Lobo R A.
Disturbances of androgen secretion and metabolism in polycystic ovary syndrome.
Clin Obstet Gynaecol.
1985;
12
633-647
6
Dunaif A.
Insulin resistance and the polycystic ovary syndrome: mechanism and implications for
pathogenesis.
Endocr Rev.
1997;
18
774-800
7
Dunaif A, Segal K R, Futterweit W, Dobrjansky A.
Profound peripheral insulin resistance, independent of obesity, in polycystic ovary
syndrome.
Diabetes.
1989;
38
1165-1174
8
Balen A H, Laven J S, Tan S L, Dewailly D.
Ultrasound assessment of the polycystic ovary: international consensus definitions.
Hum Reprod Update.
2003;
9
505-514
9
Azziz R, Marin C, Hoq L, Badamgarav E, Song P.
Health care-related economic burden of the polycystic ovary syndrome during the reproductive
life span.
J Clin Endocrinol Metab.
2005;
90
4650-4658
10
Azziz R.
Diagnostic criteria for polycystic ovary syndrome: a reappraisal.
Fertil Steril.
2005;
83
1343-1346
11
Ehrmann D A, Liljenquist D R, Kasza K, Azziz R, Legro R S, Ghazzi M N.
Prevalence and predictors of the metabolic syndrome in women with polycystic ovary
syndrome.
J Clin Endocrinol Metab.
2006;
91
48-53
12
The Rotterdam ESHRE/ASRM-sponsored PCOS consensus workshop group .
Revised 2003 consensus on diagnostic criteria and long-term health risks related to
polycystic ovary syndrome (PCOS).
Hum Reprod.
2004;
19
41-47
13
Boomsma C M, Eijkemans M J, Hughes E G, Visser G H, Fauser B C, Macklon N S.
A meta-analysis of pregnancy outcomes in women with polycystic ovary syndrome.
Hum Reprod Update.
2006;
12
673-683
14 Zawadski J, Dunaif A.
Diagnostic criteria for polycystic ovary syndrome: towards a rational approach . In: Dunaif A, Givens J, Haseltine F Polycystic Ovary Syndrome. Boston, MA; Blackwell
Scientific 1992: 377-384
15
Azziz R.
PCOS: a diagnostic challenge.
Reprod Biomed Online.
2004;
8
644-648
16
Polson D W, Adams J, Wadsworth J, Franks S.
Polycystic ovaries-a common finding in normal women.
Lancet.
1988;
1
870-872
17
Carmina E, Lobo R A.
Do hyperandrogenic women with normal menses have polycystic ovary syndrome?.
Fertil Steril.
1999;
71
319-322
18
Swanson M, Sauerbrei E E, Cooperberg P L.
Medical implications of ultrasonically detected polycystic ovaries.
J Clin Ultrasound.
1981;
9
219-222
19
Adams J, Franks S, Polson D W et al..
Multifollicular ovaries: clinical and endocrine features and response to pulsatile
gonadotropin releasing hormone.
Lancet.
1985;
2
1375-1379
20
Goldstein S R.
Incorporating endovaginal ultrasonography into the overall gynecologic examination.
Am J Obstet Gynecol.
1990;
162
625-632
21
Jonard S, Robert Y, Cortet-Rudelli C, Pigny P, Decanter C, Dewailly D.
Ultrasound examination of polycystic ovaries: is it worth counting the follicles?.
Hum Reprod.
2003;
18
598-603
22
Dewailly D, Catteau-Jonard S, Reyss A C, Maunoury-Lefebvre C, Poncelet E, Pigny P.
The excess in 2-5 mm follicles seen at ovarian ultrasonography is tightly associated
to the follicular arrest of the polycystic ovary syndrome.
Hum Reprod.
2007;
22
1562-1566
23
Conway G S, Honour J W, Jacobs H S.
Heterogeneity of the polycystic ovary syndrome: clinical, endocrine and ultrasound
features in 556 patients.
Clin Endocrinol (Oxf).
1989;
30
459-470
24
Jonard S, Robert Y, Dewailly D.
Revisiting the ovarian volume as a diagnostic criterion for polycystic ovaries.
Hum Reprod.
2005;
20
2893-2898
25
Erickson G F, Magoffin D A, Dyer C A, Hofeditz C.
The ovarian androgen producing cells: a review of structure/function relationships.
Endocr Rev.
1985;
6
371-399
26
Al-Took S, Watkin K, Tulandi T, Tan S L.
Ovarian stromal echogenicity in women with clomiphene citrate-sensitive and clomiphene
citrate-resistant polycystic ovary syndrome.
Fertil Steril.
1999;
71
952-954
27
Buckett W M, Bouzayen R, Watkin K L, Tulandi T, Tan S L.
Ovarian stromal echogenicity in women with normal and polycystic ovaries.
Hum Reprod.
1999;
14
618-621
28
Fulghesu A M, Ciampelli M, Belosi C, Apa R, Pavone V, Lanzone A.
A new ultrasound criterion for the diagnosis of polycystic ovary syndrome: the ovarian
stroma/total area ratio.
Fertil Steril.
2001;
76
326-331
29
Fulghesu A M, Angioni S, Frau E et al..
Ultrasound in polycystic ovary syndrome-the measuring of ovarian stroma and relationship
with circulating androgens: results of a multicentric study.
Hum Reprod.
2007;
22
2501-2508
30
Battaglia C, Genazzani A D, Artini P G, Salvatori M, Giulini S, Volpe A.
Ultrasonographic and color Doppler analysis in the treatment of polycystic ovary syndrome.
Ultrasound Obstet Gynecol.
1998;
12
180-187
31
Carmina E, Orio F, Palomba S, Longo R A, Lombardi G, Lobo R A.
Ovarian size and blood flow in women with polycystic ovary syndrome and their correlations
with endocrine parameters.
Fertil Steril.
2005;
84
413-419
32
Agrawal R, Sladkevicius P, Engmann L et al..
Serum vascular endothelial growth factor concentrations and ovarian stromal blood
flow are increased in women with polycystic ovaries.
Hum Reprod.
1998;
13
651-655
33
Engmann L, Sladkevicius P, Agrawal R, Bekir J S, Campbell S, Tan S L.
Value of ovarian stromal blood flow velocity measurement after pituitary suppression
in the prediction of ovarian responsiveness and outcome of in vitro fertilization
treatment.
Fertil Steril.
1999;
71
22-29
34
Agrawal R, Conway G, Sladkevicius P et al..
Serum vascular endothelial growth factor and Doppler blood flow velocities in in vitro
fertilization: relevance to ovarian hyperstimulation syndrome and polycystic ovaries.
Fertil Steril.
1998;
70
651-658
35
Raine-Fenning N J, Campbell B K, Clewes J S, Johnson I R.
The interobserver reliability of ovarian volume measurement is improved with three-dimensional
ultrasound, but dependent upon technique.
Ultrasound Med Biol.
2003;
29
1685-1690
36
Jarvela I Y, Mason H D, Sladkevicius P et al..
Characterization of normal and polycystic ovaries using three-dimensional power Doppler
ultrasonography.
J Assist Reprod Genet.
2002;
19
582-590
37
Lam P M, Raine-Fenning N.
The role of three-dimensional ultrasonography in polycystic ovary syndrome.
Hum Reprod.
2006;
21
2209-2215
38
Allemand M C, Tummon I S, Phy J L, Foong S C, Dumesic D A, Session D R.
Diagnosis of polycystic ovaries by three-dimensional transvaginal ultrasound.
Fertil Steril.
2006;
85
214-219
39
Faure N, Prat X, Bastide A, Lemay A.
Assessment of ovaries by magnetic resonance imaging in patients presenting with polycystic
ovarian syndrome.
Hum Reprod.
1989;
4
468-472
40
Yoo R Y, Sirlin C B, Gottschalk M, Chang R J.
Ovarian imaging by magnetic resonance in obese adolescent girls with polycystic ovary
syndrome: a pilot study.
Fertil Steril.
2005;
84
985-995
41
Timor-Tritsch I E, Monteagudo A, Rebarber A, Goldstein S R, Tsymbal T.
Transrectal scanning: an alternative when transvaginal scanning is not feasible.
Ultrasound Obstet Gynecol.
2003;
21
473-479
42
Azziz R, Carmina E, Dewailly D et al..
Positions statement: criteria for defining polycystic ovary syndrome as a predominantly
hyperandrogenic syndrome: an Androgen Excess Society guideline.
J Clin Endocrinol Metab.
2006;
91
4237-4245
43
Diamanti-Kandarakis E, Panidis D.
Unravelling the phenotypic map of polycystic ovary syndrome (PCOS): a prospective
study of 634 women with PCOS.
Clin Endocrinol (Oxf).
2007;
67
735-742
44
Kyei-Mensah A A, LinTan S, Zaidi J, Jacobs H S.
Relationship of ovarian stromal volume to serum androgen concentrations in patients
with polycystic ovary syndrome.
Hum Reprod.
1998;
13(6)
1437-1441
45
Dolz M, Osborne N G, Blanes J et al..
Polycystic ovarian syndrome: assessment with color Doppler angiography and three-dimensional
ultrasonography.
J Ultrasound Med.
1999;
18(4)
303-313
46
Jarvela I Y, Mason H D, Sladkevicius P et al..
Characterization of normal and polycystic ovaries using three-dimensional power Doppler
ultrasonography.
J Assist Reprod Genet.
2002;
19(12)
582-590
47
Pan H A, Wu M H, Cheng Y C, Li C H, Chang F M.
Quantification of Doppler signal in polycystic ovarian syndrome using 3D power Doppler
ultrasonography.
Hum Reprod.
2002;
17(9)
2484
48
Ng E H, Chan C C, Yeung W S, Ho P C.
Comparison of ovarian stromal blood flow between fertile women with normal ovaries
and infertile women with polycystic ovary syndrome.
Hum Reprod.
2005;
20(7)
1881-1886
49
Azziz R.
Controversy in clinical endocrinology: diagnosis of polycystic ovarian syndrome: the
Rotterdam criteria are premature.
J Clin Endocrinol Metab.
2006;
91
781-785
Misty Blanchette PorterM.D.
Division of Reproductive Medicine, Departments of Obstetrics and Gynecology and Radiology,
Dartmouth-Hitchcock Medical Center
1 Medical Center Drive, Lebanon, NH 03756
Email: Misty.B.Porter@Hitchcock.org