Planta Med 2008; 74 - P-109
DOI: 10.1055/s-2008-1075305

Flavonoids from Iris songarica

MR Moein 1, Z Ali 2, SI Khan 2, SAM Ayatollahi 3, F Kobarfard 3, S Nasim 4, IA Khan 2, 5
  • 1Department of Pharmacognosy and PharmaceuticalSciences Research Center, School of Pharmacy, ShirazUniversity of Medical Sciences, Shiraz, Iran
  • 2National Center for Natural Products Research and
  • 5Department of Pharmacognosy, Research Institute ofPharmaceutical Sciences, School of Pharmacy, University of Mississippi, MS 38677, USA
  • 3School of Pharmacy, Shaheed Beheshti University of Medical Sciences, P.O. Box 14155–6153, Tehran, Iran
  • 4H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan

The genus Iris is comprised of over 300 species and 20 are found in Iran [1,2]. Roots of I. songarica have been used to cure diarrhea in Pakistan [3]. This genus is rich in isoflavonoids which have a wide range of biological activities including anti-inflammatory, antioxidant and cancer chemopreventive properties [4]. Previous phytochemical studies on Iris revealed the presence of flavonoid, isoflavonoid, benzoquinone, triterpene, xanthone and stilbene derivatives [5]. A new dihydroflavonol, songaricol (1) and seven known flavonoids including three isoflavones, one flavone, one coumaranochromone and one peltoginoid were isolated from Iris songarica. Structure elucidation was achieved through extensive NMR and circular dichroism techniques. Acknowledgement: The work was supported by the financial support of Shiraz University of Medical Sciences, Shiraz, Iran. References: [1] Mazhari N (2000) Flora of Iran, Vol. 31. [2] Mozaffarian V (1996) Dictionary of Iranian plant names. [3] Ali SI, Matew B (1993) Iridaceae, Flora of Pakistan, Vol. 202. [4] Atta-ur-Rahman, et al. (2003) J. Ethnopharmacol. 86: 177–180. [5] Choudhary MI, et al. (2001) J. Nat. Prod. 64: 857–860.