Planta Med 2008; 74 - P-102
DOI: 10.1055/s-2008-1075298

Chemical Composition and Anti-malarial Activity of the Fraction from Dryopteris crassirhizoma Nakai

Z Gao 1, 2, J Zhao 2, Z Ali 2, Y Lu 1, IA Khan 2, 3
  • 1School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 100102, China
  • 2National Center for Natural Products Research, University of Mississippi, MS 38677, USA
  • 3Department of Pharmacognosy, School of Pharmacy,University of Mississippi, MS 38677, USA

The rhizome and leftover petiole of Dryopteris crassirhizoma Nakai is a traditional Chinese medicine to cure flu and verminosis. It is recorded in Chinese pharmacopoeia under the name of Mianma Guanzhong [1]. A chemical standardized fraction has been obtained from Mianma Guanzhong. Its anti-malarial efficacy was evaluated with Peter's test on suppressive Plasmodium berghei in a mouse malaria model. The ED50 is 59.74 mg/Kg on mice with K173 and the ED50 is 111.22 mg/Kg on mice with RC/K173. Four major compounds, dryocrassin ABAA, ABPA, ABBA, and ABBP were detected in this fraction by LC/MS/MS. Acknowledgements: Thanks to China Scholarship Council for funding assistance. We are grateful to professor Guofu Li for helping in anti-malarial activity testing. References: [1] The pharmacopoeia Commission of P. R. China. (2005) The Pharmacopoeia of P. R. China I: 231.