Phytochemical Investigation of Cissus quadrangularis Linn.

Cissus quadrangularis Linn. (Veldt Grape or Winged Treebine), a climbing vine in the family Vitaceae, is one of the most frequently used medicinal plants in Thailand and can be found throughout the country [1]. The fresh stem and leave of C. quadrangularis is used for the treatment of hemorrihoids, menstrual symptoms, scurvy and as an anti-flatulence. In India it is used for many diseases [2–3]. Previous phytochemical investigation studies of C. quadrangularis L. (Vitaceae) have led to the isolation of flavonoids, triterpenoids, stilbenes and phytosterols [4–7]. We report the isolation a new norsesqueterpinoid 9-hydroxy,10-methoxy, z-megatigmadiene-3-one (1) and known stilbenes quadrangularins A (2), quadrangularins B (3), quercetin-3-O-rhaminoside (4), quercetin-3-O-glucopyranoside (5), 9-O-glucopyranoside,10-hydroxy megatigmadiene-3-one (6) and isoengeletine (7) were further isolated from the ethanolic extract of the whole plant. Acknowledgements: The work was supported by Center of Research Excellence in Natural Products Neuroscience (CORE-NPN)NIH/NCRR grant number P20RR021929. References: [1] Pongboonrod S, (1995) Kaeseambunnakit Printing, Mai Thed Mung Muang Thai., Bangkok. Thailand, p.428–429. [2] Chopra NN, et al. (1958) Indigenous Drugs of India, In: Dhar, U. D. (Ed)., Cissus quadrangularis. Culcutta, p.669–670. [3] Yoganarsimhan SN, (2000) Medicinal Plants of India. Cyber Media Bangalore 2: 136–137. [4] Bhutani KK, et al. (1984) Phytochemistry 23(2): 407–410. [5] Gupta MM, Verma RK, (1991) Phytochemistry 29(1): 336–337. [6] Mehta M, et al. (2001) Phytochemical Analysis 12(2): 91–95. [7] Adesanya SA, et al. (1999) Journal of Natural Products 62: 1694–1695.