Planta Med 2008; 74 - P-94
DOI: 10.1055/s-2008-1075290

Antimicrobial Compounds from Gloeosporiumminus

M Kumarihamy 1, 2, NPD Nanayakkara 1, MR Jacob 1
  • 1National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, MS 38677
  • 2Department of Pharmacognosy, School of Pharmacy,University of Mississippi, University, MS 38677

Fungi have been a rich source of antimicrobial agents. As a part of our search for novel biologically active compounds from fungi a number of fungal extracts were evaluated against Candida albicans, Cryptococcus neoformans and methicillin-resistant Staphylococcus aureus. The ethyl acetate extract of Gloeosporium minus showed potent activity against C. albicans and C. neoformans. Bioassay-guided fractionation of this extract led to the isolation of a new (1) together with two previously reported [1] antifungal compounds, flavovirin (2) and myriocin (3). Acknowledgements: The authors sincerely thank Dr. Bandara Herath for recording NMR spectra. References: [1] Sailer S, et al. (1989) J. Basic Microbiol. 6: 375–381.