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Planta Med 2008; 74 - P-94
DOI: 10.1055/s-2008-1075290
DOI: 10.1055/s-2008-1075290
Antimicrobial Compounds from Gloeosporiumminus
Fungi have been a rich source of antimicrobial agents. As a part of our search for novel biologically active compounds from fungi a number of fungal extracts were evaluated against Candida albicans, Cryptococcus neoformans and methicillin-resistant Staphylococcus aureus. The ethyl acetate extract of Gloeosporium minus showed potent activity against C. albicans and C. neoformans. Bioassay-guided fractionation of this extract led to the isolation of a new (1) together with two previously reported [1] antifungal compounds, flavovirin (2) and myriocin (3). Acknowledgements: The authors sincerely thank Dr. Bandara Herath for recording NMR spectra. References: [1] Sailer S, et al. (1989) J. Basic Microbiol. 6: 375–381.