Antiproliferative Compounds of Symphoniatanalensis from Madagascar

The Investigation of the Madagascar plant Symphonia tanalensis Jum. & H. Perrier (Clusiaceae) for antiproliferative activity against A2780 ovarian cancer cell line led to the isolation of four guttiferone analogs and one xanthone derivative. On the basis of 1D and 2D NMR spectroscopic data, the xanthone derivative 1 was determined to be a new natural product. The structure elucidation of the guttiferones will be reported. Compound 1 showed antiproliferative activitiy against the A2780 human ovarian cancer cell line with an IC50 value of 3.3 µg/mL, and the guttiferone analogs exhibited similar activities with IC50 values around 3 µg/mL. Acknowledgements: This project was supported by the Fogarty International Center, the National Cancer Institute, the National Science Foundation, the National Heart, Lung and Blood Institute, the National Institute of Mental Health, the Office of Dietary Supplements, and the Office of the Director of NIH, under Cooperative Agreement U01 TW000313 with the International Cooperative Biodiversity Groups, and this support is gratefully acknowledged.