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Planta Med 1980; 38(1): 18-23
DOI: 10.1055/s-2008-1074832
Research Articles

© Georg Thieme Verlag Stuttgart · New York

Preparation of Anti-lipolytic Substance from Panax ginseng

T. Ando, T. Muraoka, N. Yamasaki1 , H. Okuda
  • 2nd Department of Medical Biochemistry, School of Medicine, Ehime University, Onsen-gun, Ehime, Japan.
  • 1Laboratory of Biochemistry, Faculty of Agriculture, Kyushu University, Fukuoka, Japan.
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Publication History

Publication Date:
29 April 2008 (online)

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Abstract

It was found that water extract of Panax ginseng strongly inhibited adrenaline-induced lipolysis in isolated fat cells of rat epididymal adipose tissue. Anti-lipolytic action of the water extract was easily inactivated by treatment with pronase, suggesting that the active principle might be a protein or a peptide. The water extract was dialyzed against distilled water. The outer dialysate was treated with DEAE-cellulose and the eluate was subjected to gel filtration on Sephadex G-50 column, Avicel cellulose column chromatography and phosphocellulose column chromatography, successively. With these procedures, a peptide (P II), which had anti-lipolytic activity, was isolated in a purified form.

Key Word Index

Panax ginseng - Araliaceae - Anti-lipolytic Substance - Fat Cells - Adrenaline-induced Lipolysis.

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