New Bioactive Bromotyrosine-Derived Alkaloid from a Marine Sponge Aplysinella sp.

Abstract

A new bromotyrosine-derived alkaloid, (+)-aplysinillin (1), together with seven known compounds, was isolated from the crude organic extract of the marine sponge Aplysinella sp. collected from the Federated States of Micronesia. The structure of 1 was deduced by NMR and mass spectral techniques. Compounds 1 - 8 were evaluated for their inhibitory activity with the hyphae formation inhibition assay in Streptomyces 85E. Compounds 1 and 8 exhibited antiproliferative activities against the human breast adenocarcinoma cancer cell line MCF-7.

Key words

Bromotyrosine alkaloids - protein phosphorylation inhibitors - marine sponge, Aplysinella sp. - hyphae formation inhibition

References

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