Two New Cytotoxic Pregnane Glycosides from Cynanchum auriculatum

Abstract

Two new pregnane glycosides, kidjoranin 3-O-α-diginopyranosyl-(1→4)-β-cymaropyranoside (1) and kidjoranin 3-O-β-digitoxopyranoside (2), together with one known compound caudatin 3-O-β-cymaropyranoside (3), were isolated from the roots of Cynanchum auriculatum. Their structures were established on the basis of NMR analyses. Compounds 1 - 3 were tested for their in vitro inhibitory activity against the growth of human tumor cell lines SMMC-7721, HeLa and MCF7; all of them displayed marked cytotoxic activities against cells SMMC-7721 and HeLa with IC₅₀ values ranging from 8.6 μM to 58.5 μM, yet no activity against the cell line MCF7 was detected.

Key words

Cynanchum auriculatum - Asclepiadaceae - pregnane glycosides - cytotoxic activity

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