Horm Metab Res 2008; 40(6): 361-368
DOI: 10.1055/s-2008-1073153
Review

© Georg Thieme Verlag KG Stuttgart · New York

Chemokines and Autoimmune Thyroid Diseases

C. Liu 1 , C. Papewalis 2 , J. Domberg 2 , W. A. Scherbaum 2 , M. Schott 2
  • 1Department of Endocrinology, First Affiliated Hospital, Nanjing Medical University, Nanjing, China
  • 2Department of Endocrinology, Diabetes and Rheumatology, University Hospital Düsseldorf, Düsseldorf, Germany
Further Information

Publication History

received 19.12.2007

accepted 23.01.2008

Publication Date:
16 April 2008 (online)

Abstract

Chemokines are a family of small, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with their seven-transmembrane, G protein-coupled receptors. Their major function is the recruitment of leukocytes to inflammation sites, but they also play roles in tumor growth, angiogenesis, organ sclerosis, and autoimmunity. A variety of evidence has accumulated to support the concept that thyroid follicular cells as well as intrathyroidal lymphocytes are able to produce CC and CXC chemokines, which, in turn, promote the initiation and maintenance of an inflammatory process resulting in autoimmune thyroid diseases (AITD). Overexpression of several chemokines in AITD has been demonstrated. Moreover, alterations of CCL2, CCL5, CXCL9, and CXCL10 have been shown in circulation of many patients with AITD. In subjects with Graves’ disease, antithyroid drug treatment, radioactive iodine ablation, and thyroidectomy can significantly reduce CXCL10 levels. The measurement of chemokines in serum of AITD patients might provide a useful parameter for the evaluation and prediction of disease activity and progression. Further experimental and clinical studies will expand our understanding of the clinical implications of chemokine detection and the effects of chemokines on the pathogenesis of AITD.

References

Correspondence

M. Schott, MD 

Department of Endocrinology

Diabetes and Rheumatology

University Hospital Düsseldorf

Moorenstr. 5

40225 Düsseldorf

Germany

Phone: +49/211/811 78 10

Fax: +49/211/811 78 60

Email: matthias.schott@med.uni-duesseldorf.de