Management of Skull Base Defect with bFGF after Extensive Skull Base Surgery - Two Case Reports

Abstract

The basic fibroblast growth factor (bFGF) is one of the most powerful growth factors to promote wound healing. In this paper we describe two cases of skull base tumor requiring extensive skull base reconstruction, in which the application of bFGF was effective in the management and prevention of CSF leaks. The role and safeness of bFGF for skull base reconstruction are discussed.

Key words

basic fibroblast growth factor - bFGF - anterior skull base - reconstruction

References

• 1 Thomas K. Fibroblast growth factors.  FASEB J. 1987;  6 434-440
• 2 Baird A, Esch F, Mormede P. Molecular characterization of fibroblast growth factor: distribution and biological activities in cvarious tissues.  Recent Prog Horm Res. 1996;  42 143-205
• 3 Robson MC, Hill DP, Smith PD. et al . Sequential cytokine therapy for pressure ulcers: Clnical and mechanistic response.  Ann Surg. 2000;  231 600-611
• 4 Robson MC, Phillips LG, Lawrence WT. et al . The safety and effect of topically applied recombinant basic fibroblast growth factor on the healing of chronic pressure sores.  Ann Surg. 2000;  216 401-408
• 5 Hakuba N, Taniguchi M, Shimizu Y. et al . A new method for closing tympanic membrane perforations using basic fibroblast growth factor.  Laryngoscope. 2003;  113 1352-1355
• 6 Kubo S, Inui T, Hasegawa H, Yoshimine T. Repair of intractable cerebrospinal fluid rhinorrhea with mucosal flaps and recombinant human basic fibroblast growth factor: technical case report.  Neurosurgery. 2005;  56 E627
• 7 Obeid F, Al-Mefty O. Recurrence of olfactory groove meningiomas.  Neurosurgery. 2003;  53 534-542 , ; discussion 542-543
• 8 Hendryk S, Czecior E, Misiolek M, Namyslowski G, Mrowka R. Surgical strategies in the removal of malignant tumors and benign lesions of the anterior skull base.  Neurosurg Rev. 2004;  27 205-213
• 9 Georgantopoulou A, Hodgkinson PD, Gerber CJ. Cranial-base surgery: a reconstructive algorithm.  Br J Plast Surg. 2003;  56 10-13
• 10 Gok A, Erkutlu I, Alptekin M, Kanlikama M. Three-layer reconstruction with fascia lata and vascularized pericranium for anterior skull base defects.  Acta Neurochir (Wien). 2004;  146 53-56
• 11 Rodrigues M, O'malley  BW, Staecker H, Tamargo R. Extended pericranial flap and bone graft reconstruction in anterior skull base surgery.  Otolaryngol Head Neck Surg. 2004;  131 69-76
• 12 Sinha UK, Johnson TE, Crockett D, Vadapalli S, Gruen P. Three-layer reconstruction for large defects of the anterior skull base.  Laryngoscope. 2002;  112 424-427
• 13 Schliephake H, Jamil MU. et al . Experimental reconstruction of the mandible using polylactic acid tubes and basic fibroblast growth factor in alloplastic scaffolds.  J Oral Maxillofac Surg. 1998;  56 616-626 , ; discussion 626-627
• 14 Wildburger R, Zarkovic N. et al . Basic fibroblast growth factor (BFGF) immunoreactivity as a possible link between head injury and impaired bone fracture healing.  Bone Miner. 1994;  27 183-192
• 15 Whitby DJ, Ferguson MW. Immunohistochemical localization of growth factors in fetal wound healing.  Dev Biol. 1991;  147 207-215
• 16 Eppley BL, Connolly DT. et al . Free bone graft reconstruction of irradiated facial tissue: experimental effects of basic fibroblast growth factor stimulation.  Plast Reconstr Surg. 1991;  88 1-11
• 17 Eppley BL, Doucet M. et al . Enhancement of angiogenesis by bFGF in mandibular bone graft healing in the rabbit.  J Oral Maxillofac Surg. 1988;  46 391-398
• 18 Duynstee ML, Verwoerd-Verhoef HL. et al . The dual role of perichondrium in cartilage wound healing.  Plast Reconstr Surg. 2002;  110 1073-1079
• 19 Oskouian RJ, Jane JA, Dumont AS. et al . Esthesioneuroblatoma: clinical presentation, radiological and pathological features, treatment, review of the literature, and the University of Virginia experience.  Neurosurg Focus. 2002;  12 1-9
• 20 Faber-Elman A, Solomon A. et al . Involvement of wound-associated factors in rat brain astrocyte migratory response to axonal injury: in vitro simulation.  J Clin Invest. 1996;  97 162-171
• 21 Logan A, Berry M. Transforming growth factor-beta 1 and basic fibroblast growth factor in the injured CNS.  Trends Pharmacol Sci. 1993;  14 337-342
• 22 Olson L. Grafts and growth factors in CNS. Basic science with clinical promise.  Stereotact Funct Neurosurg. 1990;  54-55 250-267
• 23 Spector JA, JGreenwald JA. et al . Dura mater biology: autocrine and paracrine effects of fibroblast growth factor 2.  Plast Reconstr Surg. 2002;  109 645-654
• 24 Tachibana E, Saito K. et al . Evaluation of the healing process after dural reconstruction achieved using a free fascial graft.  J Neurosurg. 2002;  96 280-286
• 25 Mazue G, Bertolero M, Jacob C. et al . Preclinical and clinical studies with recombinant human basic fibroblast growth factor.  Ann N Y Acad Sci. 1991;  638 329-340
• 26 Friedman NR, Wright CG, Pawlowski KS. et al . Effect of basic fibroblast growth factor on perforated chinchilla tympanic membranes.  Ear Nose Throat J. 1997;  76 559-564

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