Synlett 2008(8): 1125-1128
DOI: 10.1055/s-2008-1072717
DOI: 10.1055/s-2008-1072717
LETTER
© Georg Thieme Verlag Stuttgart · New YorkMicrowave-Assisted Hydrogenation of Pyridines
Weitere Informationen
Received
19 January 2008
Publikationsdatum:
16.April 2008 (eFirst)
Publikationsverlauf
Publikationsdatum:
16.April 2008 (eFirst)

Abstract
Using a commercially available device for controlled introduction of hydrogen in a vial for reactions under microwave dielectric heating, we developed a protocol for the transformation of substituted pyridines into the corresponding piperidines. Complete reduction occurred in 40 minutes, or even less, on substrates that require 24-48 hours to be reduced under standard conditions. Moreover, the reduction proved to be as stereoselective as the corresponding reaction carried out at room temperature.
Key words
microwave - hydrogenation - piperidines - heterogeneous catalysis