Microwave-Assisted Hydrogenation of Pyridines

doi:10.1055/s-2008-1072717

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Synlett 2008(8): 1125-1128
DOI: 10.1055/s-2008-1072717

LETTER

Microwave-Assisted Hydrogenation of Pyridines

Leonarda Piras^a, Eva Genesio^b, Chiara Ghiron^b, Maurizio Taddei*^a
^a Dipartimento Farmaco Chimico Tecnologico, Università degli Studi di Siena, Via A. Moro, 53100 Siena, Italy
Fax: +39(0577)234333; e-Mail: taddei.m@unisi.it;
^b Siena Biotech SpA, Via Fiorentina 1, 53100 Siena, Italy

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Received 19 January 2008
Publikationsdatum:
16.April 2008 (eFirst)

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Abstract

Using a commercially available device for controlled introduction of hydrogen in a vial for reactions under microwave dielectric heating, we developed a protocol for the transformation of substituted pyridines into the corresponding piperidines. Complete reduction occurred in 40 minutes, or even less, on substrates that require 24-48 hours to be reduced under standard conditions. Moreover, the reduction proved to be as stereoselective as the corresponding reaction carried out at room temperature.

Key words

microwave - hydrogenation - piperidines - heterogeneous catalysis