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Neuropediatrics 1993; 24(2): 111-112
DOI: 10.1055/s-2008-1071525
Letter to the editors

© Georg Thieme Verlag KG Stuttgart · New York

Proton in Vivo Spectroscopy of Patients with Hyperphenylalaninaemia

M.  Hájek1 , Ludmila  Hejcmanová2 , J.  Přádný3
  • 1MR Department, Institute for Clinical and Experimental Medicine, Videňscá 800, 14000 Praha, Czech Republic
  • 2Department of Pediatrics, 3rd Medical School, Charles University, Vinohradská 159, 10081 Praha, Czech Republic
  • 3MR Unit, Radiological Clinic, Šrobárova 50, 10081 Praha, Czech Republic
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Publikationsdatum:
19. März 2008 (online)

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Abstract

Changes in MR images and 1H spectra of 20 patients with hyperphenylalaninaemia were compared with data of controls. Major changes in T2 MR images were found in the periventricular area (20/19). Some patients showed lesions in MR images of basal ganglia (20/7) and in the cerebellum (20/4). The results of proton MR spectroscopy show no significant difference for NAA/Cr ratios but significant ones between the ratios of NAA/Cho (p = 0.97) and Cho/Cr (p = 0.98) of controls and patients with hyperphenylalaninaemia.

Key words

Hyperphenylalaninaemia - 1H MR spectroscopy - N-acetylaspartate - Choline - Creatine - MRI