© Georg Thieme Verlag KG Stuttgart · New York
Immunotherapy with Stimulated Autologous Lymphocytes in a Case of a Juvenile Anaplastic Glioma** Supported by the „Deutsche Forschungsgemeinschaft”
19 March 2008 (online)
The effect of immunotherapy with stimulated autologous lymphocytes (SAL) in malignant gliomas is documented and discussed in a bioptical and autoptical case study. A five-year-old child with a recurrently operated and radiated right hemispheric anaplastic astrocytoma died six weeks after immunotherapy with mitogen-activated killer cells and recombinant Interleukin-2. The autopsy revealed a large butterfly glioma with partially necrotic gelatinous tissue at the site of the SAL reservoir. The tumor cell density on the right was less than on the left hemisphere, and T-lymphocyte content was higher on the right hemisphere. These results demonstrate a local effect of SAL therapy in vivo, although the tumor progression as a whole could not be stopped. They also demonstrate the need of a detailed neuropathological examination in all cases of immunotherapy of malignant gliomas.
Glioma - LAK-cell therapy - Interleukin 2 - T-lymphocytes