Semin Reprod Med 1997; 15(3): 301-308
DOI: 10.1055/s-2008-1068760
Copyright © 1997 by Thieme Medical Publishers, Inc.

Does Disruption of Immune and Endocrine Systems by Environmental Toxins Contribute to Development of Endometriosis?

Kevin G. Osteen, Elaine Sierra-Rivera
  • Reproductive Medicine Research Laboratory, Department of Obstetrics and Gynecology, Vanderbilt University School of Medicine, Nashville, Tennessee
Further Information

Publication History

Publication Date:
15 March 2008 (online)

Abstract

The proper function of the normal human endometrium relies on well organized cell-cell interactions regulated locally by cytokines and growth factors under the direction of steroid hormones. The onset and progression of the disease processes of endometriosis may result from disruptions of this well balanced cellular equilibrium. Evidence continues to accumulate indicating that environmental toxins, whether naturally occurring or man-made, may directly (hormone disruptor) or indirectly (immune toxin) affect the response of the endometrium to steroids, resulting in various pathological states including endometriosis.

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