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DOI: 10.1055/s-2008-1067332
© Georg Thieme Verlag KG Stuttgart · New York
Den Krebs bremsen?
Einfluss sekundärer Pflanzenstoffe auf die adipozytenstimulierte Proliferation von HT29-ZellenHow to Slow Down Cancer?Influence of Secondary Plant Metabolites on the Adipocyte-Stimulated Proliferation of HT29 CellsPublication History
Publication Date:
30 April 2008 (online)
Zusammenfassung
Adipositas ist mit einem erhöhten Risiko für Kolonkarzinome assoziiert. Das Fettgewebe sezerniert eine Reihe von biofunktionellen Faktoren, sogenannte Adipokine. Diese führen unter bestimmten Bedingungen zu einem Wachstum von HT29-Zellen. Z. B. wurde für Leptin eine proliferationsfördernde Wirkung beschrieben, die jedoch in einem Modell mit der Verwendung von Fettzellüberständen nicht bestätigt werden konnte. Vermutlich sezernieren Fettgewebszellen sowohl proliferationsfördernde als auch proliferationshemmende Substanzen. Diverse sekundäre Pflanzenstoffe scheinen proliferationshemmendes und damit tumorprotektives Potenzial zu besitzen.
Abstract
Adiposity is associated with an increased risk for colon cancer. Adipose tissue is secreting a variety of factors, the so-called adipokines. Under particular conditions adipokines promote the growth of HT29 cells. Leptin for example has a proliferating effect which could not be confirmed in experiments using supernatants of fat cells. It is assumed that cells from adipose tissue secrete substances which display promoting or inhibiting characteristics. A variety of secondary plant metabolites might inhibit proliferation and hence could have tumour-protective potential.
Schlüsselwörter
Adipositas - Kolonkarzinom - Leptin - HT29-Zellen - sekundäre Pflanzenstoffe
Key words
adiposity - colon cancer - leptin - HT29 cells - secondary plant metabolites
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Dr. Thomas Skurk
Else-Kröner-Fresenius-Zentrum für Ernährungsmedizin
Hochfeldweg 1
83530 Freising-Weihenstephan
Phone: 08161/712001
Fax: 08161/712097
Email: ernaehrungsmedizin@wzw.tum.de