A Convenient Route to Trifluoromethyl-Substituted Cyclopropane Derivatives
29 April 2008 (eFirst)
A range of alkenes have been converted in a single step into the corresponding trifluoromethyl-substituted cyclopropanes by treatment with 2-diazo-l,l,l-trifluoroethane over metal catalysts. Application of the Gaspar-Roth procedure allowed the preparation of target compounds on a multi-gram scale. The practical utility of this reaction has been demonstrated by the synthesis of both diastereoisomers of the non-natural amino acid trifluoronorcoronamic acid in two steps.
fluorine - alkenes - amino acids - catalysts - diazo compounds