Exp Clin Endocrinol Diabetes 2008; 116(9): 558-560
DOI: 10.1055/s-2008-1062711
Short Communication

© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Role of Hyperglycemia in Isogeneic Islet Transplantation: An Experimental Animal Study

I. Nomikos 1 , K. Kalogerakos 1 , E. Athanasiou 2 , E. Plakokefales 3 , D. Sioutopoulou 2 , M. Satra 2 , N. C. Vamvakopoulos 2
  • 1Department of Surgery (B’ Unit), “METAXA” Cancer Memorial Hospital, Piraeus, Greece
  • 2Department of Surgery, Medical School, University of Thessaly, Larissa, Greece
  • 3Department of Biology and Genetics, Medical School, University of Thessaly, Larissa, Greece
Further Information

Publication History

received 24.01.2008 first decision 18.02.2008

accepted 18.02.2008

Publication Date:
13 May 2008 (online)

Abstract

Objective: Study the role of hyperglycemia-induced β cell loss on grafted islet destruction.

Design: Male inbred rats were made diabetic by streptozotocin administration and used as islet donors and/or isograft recipients to probe directly the role of hyperglycemia as an important determinant of transplanted islet fate, following exclusion of immune-related causes of islet graft destruction like allograft immunity and disease recurrence.

Results: Our studies showed that: a) Hyperglycemia destroyed islet but not pituitary isografts and b) Tight control of normoglycemia by sufficient islet mass engraftment prevented graft damage.

Conclusion: While sustained hyperglycemia caused destruction of transplanted islet isografts, induction of normoglycemia by transplantation of sufficient islet mass to diabetic recipients had a beneficial long term effect on their functional engraftment.

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Correspondence

Dr. M. SatraPhD 

Department of Biology

University of Thessaly

Papakuriazi -22

41 221 Larissa

Greece

Phone: +30/56/50 74

Email: msatra@med.uth.gr