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Neuropediatrics 1981; 12(3): 287-291
DOI: 10.1055/s-2008-1059659
© Georg Thieme Verlag KG Stuttgart · New York

SLEEP PATTERNS IN THE "NEW VARIANT" PHENYLKETONURIA

F.  Salomon , I.  Fagioli , F.  Rey , P.  Salzarulo
  • Inserm U3, 47 Blvd de l'Hôpital, Paris 13eme, France and Inserm U12, Hôpital des Enfants Malades, Paris
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Publikationsdatum:
19. März 2008 (online)

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Abstract

Sleep patterns have been investigated in a "new variant" Phenylketonuric child suffering from a deficit in dihydropteridin reductase with consequent deficit of 5-HT and dopamine. This child has been studied in four conditions: when receiving a diet poor in phenylalanine, after an intraveinous perfusion of phenylalanine and 10 days and 6 months after a treatment with L-DOPA and 5-HTP. In the three first conditions, no modifications in the amount of each state of sleep were observed; in the fourth condition the amount of paradoxical sleep was very low.

Key words

PKU "new variant" - sleep patterns - 5-HT - dopamine