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DOI: 10.1055/s-2008-1058087
© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York
The Effects of Rosiglitazione on Renal Artery Endothelium in Diabetic Rats
Publication History
received 15.10.2007
first decision 27.11.2007
accepted 11.02.2008
Publication Date:
17 March 2008 (online)
Abstract
Backround: Macrovascular disease is a common complication of Diabetes Mellitus (DM). Study of renal artery endothelium may serve as a surrogate for cardiovascular and renal vascular disease.
Object: This study is to elucidate (1) how about the changes of renal endothelial ultrastructures it is in different time of diabetes animals? (2) Whether PPARgamma ligand (such as rosiglitazone: ROS) could improve endothelium destruction in diabetes?
Methods: Streptozoticin (STZ) induced diabetic rats were stratified by age groups from 6 to 10 weeks of age and were paired with age-matched control non-diabetic rats. Further, another group of diabetic rats were treated with ROS and matched with non-treated diabetic rats.
Result: The renal artery endothelium of diabetic rats was partially coarse, distended, cracked and destroyed. The Vascular Endothelial Structure Score (VESS) was 34.5 in diabetic rats compared with non-diabetic control male rats (P=0.001). The older rats demonstrated more endothelial wall damage, more pronounced in male rats. Compared with non-treated control diabetic rats, ROS prevented diabetic endothelial damage (VESS=4.6, P=0.001).
Conclusion: Renal artery endothelium damage in STZ induced diabetic rats was significantly attenuated by rosiglitazone.
Key words
diabetes - renal artery - endothelial - rosiglitazione
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Correspondence
Y. L. Lu
Department of Endocrinology and Metabolism
Shanghai Ninth People's Hospital affiliated Shanghai Jiaotong University School of Medicine
200011 Shanghai
China
Phone: +86/21/6313 83 41
Fax: +86/21/6316 67 38
Email: luyingli2008@126.com