The effect of immunotoxin against human glioma cells

Y. Manome; M. Watanabe; T. Ohno

doi:10.1055/s-2008-1054024

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Minim Invasive Neurosurg 1989; 32(5): 146-149
DOI: 10.1055/s-2008-1054024

Originalarbeiten - Articles

The effect of immunotoxin against human glioma cells

Auswirkung von Immunotoxinen auf die menschlichen GliomzellenY. Manome¹ , M. Watanabe, T. Ohno²

¹Department of Neurosurgery
²Department of the 1^st Microbiology
Jikei University School of Medicine, Tokyo, Japan

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Publication History

Publication Date:
18 March 2008 (online)

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Summary

The authors produced immunotoxin by coupling the diphtheria toxin fragment A to the monoclonal antibody against a human glioma cell line. This toxin selectively inhibited protein synthesis of glioma cells in culture

Zusammenfassung

Immunotoxine wurden durch eine Verbindung von Fragment A des Diphterie-Toxins mit monoklonalen Antikörpern gegen die menschliche Gliomzell Linie erzeugt. Diese Toxine bewirkten eine selektive Unterdrückung der Gliomzellen-Eiweißsynthese in der Kultur

Key-words

Immunotoxin - Glioma cells