Neuropediatrics 1987; 18(4): 227-230
DOI: 10.1055/s-2008-1052486

© Georg Thieme Verlag KG Stuttgart · New York

Familial Occurrence of Intracranial Aneurysms in Childhood:
A Case Report and Review of the Literature

H. W.M. ter Berg1 , J. B. Bijlsma2 , J.  Willemse3
  • 1Department of Child Neurology, University Hospital Utrecht, Catharijnesingel 101, 3511 GV Utrecht, and Department of Neurology,Regional Hospital Almelo, Almelo, The Netherlands
  • 2Center of Clinical Genetics, 3511 GV Utrecht, The Netherlands
  • 3Department of Child Neurology, University Hospital Utrecht, Catharijnesingel 101,3511 GV Utrecht, The Netherlands
Further Information

Publication History

Publication Date:
19 March 2008 (online)


This report describes three individuals belonging to one family, who were affected with ruptured intracranial aneurysms (IAs) at a rather young age, 4, 15 and 23 years respectively. Familial IAs at this young age have not been described before.
The evidence for a developmental, eventually inherited origin of familial IA in childhood is discussed with reference to the low occurrence of non-familial IA in childhood, IA-features in non-familial cases (localisation, multiplicity, size) and the association with (other) congenital malformations in the 0-5 years group.