The definition of multiple sclerosis (MS) is problematic. MS is best appreciated as
a series of syndromes with unique but overlapping clinical and pathological features.
Each has a distinct prognosis. Prototypic MS is a relapsing-remitting disease that
culminates in a secondarily progressive course in most patients. Several clinical
and demographic features permit stratification of patients according to risk of advanced
permanent disability. It will be critical to determine if currently available “long-term
treatments” truly have an impact on the long-term course of MS.
Multiple sclerosis - inflammatory demyelinating diseases - prognosis - natural history
