Semin Neurol 1998; 18(1): 7-18
DOI: 10.1055/s-2008-1040857
© 1998 by Thieme Medical Publishers, Inc.

Approach to Peripheral Neuropathy and Neuronopathy

Richard J. Barohn
  • Department of Neurology, University of Texas Southwestern Medical Center, Dallas, Texas
Further Information

Publication History

Publication Date:
19 March 2008 (online)


Neuropathic disorders encompass those that affect the neuron's cell body or neuronopathies, those affecting the peripheral process, or peripheral neuropathies. The peripheral neuropathies can be broadly subdivided into the myelinopathies and axonopathies. These conditions can be hereditary or acquired. Each of these disorders has distinct clinical features that enable neurologists to recognize the various patterns of presentation. Once a particular pattern is established, further laboratory studies including electrophysiologic testing, nerve biopsy, and blood and cerebrospinal fluid examination can be performed to confirm the clinical impression. Therapy is available in some to correct the underlying disease state or at least to improve symptoms.