Rare Tumor of the Tracheobronchial Tree: Solitary Squamous Papilloma

Abstract

A 64-year-old woman presented with an intractable cough and purulent sputum, and a chest CT revealed a mass within the left lower lobar bronchial orifice. A flexible bronchoscopy demonstrated a red, glistening, nodular single lesion, obstructing the lumen of the left lower lobe of the bronchus, and biopsy of the specimen showed squamous papilloma. Surgical resection was selected for the definite treatment, and a simple left lower lobectomy was performed. Histopathological examination revealed a 1.2 × 1.0 cm sized bronchial obstructing mass and the diagnosis of squamous papilloma was confirmed with low p53, Ki-67 (less than 5 %) and focal weak positive CEA expression. The patient had an uncomplicated postoperative course and remains asymptomatic 3 months afterwards.

Key words

Thoracic surgery - benign lung tumor - squamous papilloma

Reference

• 1 Drennan J M, Douglas A C. Solitary papilloma of a bronchus.  J Clin Pathol. 1965;  18 401-402
• 2 Katial R K, Ranlett R, Whitlock W L. Human papilloma virus associated with solitary squamous papilloma complicated by bronchiectasis and bronchial stenosis.  Chest. 1994;  106 1887-1889
• 3 Litzky L. Epithelial and soft tissue tumors of the tracheobronchial tree.  Chest Surg Clin N Am. 2003;  13 1-40
• 4 Laubscher F A. Solitary squamous papilloma of bronchial origin.  Am J Clin Pathol. 1969;  52 599-603
• 5 Popper H H, el-Shabrawi Y, Wockel W. et al . Prognostic importance of human papilloma virus typing in squamous cell papilloma of the bronchus: comparison of in situ hybridization and the polymerase chain reaction.  Hum Pathol. 1994;  25 1191-1197
• 6 Inoue Y, Oka M, Ishii H, Kimino K, Kishikawa M, Ito M. et al . A solitary bronchial papilloma with malignant changes.  Intern Med. 2001;  40 56-60
• 7 Harada H, Miura K, Tsutsui Y. et al . Solitary squamous cell papilloma of the lung in a 40-year-old woman with recurrent laryngeal papillomatosis.  Pathol Int. 2000;  50 431-439
• 8 Miura H, Tsuchida T, Kawate N, Konaka C, Kato H, Ebihara Y. Asymptomatic solitary papilloma of the bronchus: review of occurrence in Japan.  Eur Respir J. 1993;  6 1070-1073