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DOI: 10.1055/s-2008-1034293
© Georg Thieme Verlag KG Stuttgart · New York
Cancer Chemopreventive Activity of Terpenoid Coumarins from Ferula Species
Publikationsverlauf
Received: August 6, 2007
Revised: December 25, 2007
Accepted: January 3, 2008
Publikationsdatum:
31. Januar 2008 (online)
Abstract
Several natural products have been found to have anti-tumor promoting activity. In the present study, we carried out a primary screening of ten terpenoid coumarins isolated from plants of the Ferula species, examining their possible inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol 13-acetate (TPA) in Raji cells. Auraptene (7-geranyloxycoumarin, 1) and umbelliprenin (7-farnesyloxycoumarin, 2) were found to significantly inhibit EBV-EA activation and preserved the high viability of Raji cells, suggesting that they might be valuable anti-tumor-promoting agents (IC50 8.3 and 9.1 nM, respectively). Our findings revealed that the presence of a prenyl moiety in the terpenoid coumarins plays an important role in anti-tumor promoting activity as previously reported for xanthones, coumarins, flavonoids and phenylpropanoids.
Key words
Apiaceae - Ferula - anti-tumor promoting effect - terpenoid coumarins - Epstein-Barr virus activation assay - cancer chemoprevention
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Dr. Mehrdad Iranshahi
Department of Pharmacognosy and Biotechnology
Biotechnology Research Center
Faculty of Pharmacy
Mashhad University of Medical Sciences (MUMS)
P.O.Box: 91775-1365
Mashhad
Iran
Telefon: +98-511-882-3255-66
Fax: +98-511-882-3251
eMail: Iranshahim@mums.ac.ir
- www.thieme-connect.de/ejournals/toc/plantamedica