Subscribe to RSS
DOI: 10.1055/s-2008-1034285
© Georg Thieme Verlag KG Stuttgart · New York
Anti-Allergic Prenylated Flavonoids from the Roots of Sophora flavescens
Publication History
Received: May 12, 2007
Revised: November 14, 2007
Accepted: December 14, 2007
Publication Date:
24 January 2008 (online)
Abstract
The bioassay-guided fractionation of the MeOH extract from the root of Sophora flavescens led to the isolation of eight known prenylated flavonoids (1 - 8) responsible for the in vitro anti-allergic activity. Among them, kushenol N (3), sophoraflavanone G (6), and leachianone A (7) demonstrated significant inhibition of the release of β-hexosaminidase from cultured RBL-2H3 cells with IC50 values ranging from 15 to 30 μM.
Key words
Sophora flavescens - Leguminosae - anti-allergic activity - prenylated flavonoids
References
- 1 Blank U, Ra C, Miller L, White K, Metzger H, Kinet J P. Complete structure and expression in transfected cells of high affinity IgE receptor. Nature. 1989; 337 187-9
- 2 Kinet J P. The high-affinity receptor for IgE. Curr Opin Immunol. 1989; 2 499-505
- 3 Reth M. Antigen receptor tail clue. Nature. 1989; 338 383-4
- 4 Cambier J C. Antigen and Fc receptor signaling. The awesome power of the immunoreceptor tyrosine-based activation motif (ITAM). J Immunol. 1995; 155 3281-5
- 5 Rivera J. Molecular adapters in Fc(epsilon)RI signaling and the allergic response. Curr Opin Immunol. 2002; 14 688-93
- 6 Ryu S Y, Oak M H, Kim K M. Inhibition of mast cell degranulation by tanshinones from the roots of Salvia miltiorrhiza. . Planta Med. 1999; 65 654-5
- 7 Ryu S Y, Kou N Y, Choi H S, Ryu H, Kim T S, Kim K M. Cnidicin, a coumarin, from the root of Angelica koreana, inhibits the degranulation of mast cell and the NO generation in RAW 264.7 cells. Planta Med. 2001; 67 172-4
- 8 Schwartz L B, Austen K F, Wasserman S I. Immunologic release of beta-hexosaminidase and beta-glucuronidase from purified rat serosal mast cells. J Immunol. 1979; 123 1445-50
- 9 Choi O H, Kim J H, Kinet J P. Calcium mobilization via sphingosine kinase in signalling by the Fc epsilon RI antigen receptor. Nature. 1996; 380 634-6
- 10 Oak M H, Cheong H, Kim K M. Activation of Fc epsilon RI inhibits the pyruvate kinase through direct interaction with the gamma-chain. Int Arch Allergy Immunol. 1999; 119 95-100
- 11 Jakupovic J, Paredes L, Bohlmann F, Watson L. Prenyly flavanes from Marshallia species. Phytochemistry. 1988; 27 3273-5
- 12 Kang S S, Kim J S, Son K H, Chang H W, Kim H P. A new prenylated flavanone from the roots of Sophora flavescens. . Fitoterapia. 2000; 71 511-5
- 13 Ryu S Y, Lee H S, Kim Y K, Kim S H. Determination of isoprenyl and lavandulyl positions of flavonoids from Sophora flavescens by NMR experiment. Arch Pharm Res. 1997; 20 491-5
- 14 Kang T H, Jeong S J, Ko W G, Kim N Y, Lee B H, Inagaki M. et al . Cytotoxic lavandulyl flavanones from Sophora flavescens. . J Nat Prod. 2000; 63 680-1
- 15 Iinuma M, Tanaka T, Mizuno M, Shirataki Y, Yokoe I, Komatsu M. et al . Two flavanones in Sophora leachiano and some related structures. Phytochemistry. 1990; 29 2667-9
1 Both authors contributed equally
Dr. Kyeong-Man Kim
Department of Pharmacology
College of Pharmacy
Chonnam National University
Kwang-Ju 500-757
Korea
Phone: +82-62-530-2936
Fax: +82-62-530-2949
Email: kmkim@chonnam.ac.kr