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Synthesis 2008(5): 795-799  
DOI: 10.1055/s-2008-1032184
PAPER
© Georg Thieme Verlag Stuttgart · New York

Copper(I) Oxide Catalyzed N-Arylation of Azoles and Amines with Arylboronic Acid at Room Temperature under Base-Free Conditions

Bojja Sreedhar*, Gopaladasu T. Venkanna, Kota Balaji Shiva Kumar, Vura Balasubrahmanyam
Inorganic and Physical Chemistry Division, Indian Institute of Chemical Technology, Hyderabad 500 007, India
Fax: +91(40)27160921; e-Mail: sreedharb@iict.res.in;
Further Information

Publication History

Received 17 October 2007
Publication Date:
18 February 2008 (online)

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Abstract

N-Arylation of azoles and amines with arylboronic acids was efficiently carried out with heterogeneous copper(I) oxide in methanol at room temperature under base-free conditions. The products N-arylazoles and N-arylamines were isolated in good to excellent yields. A variety of arylboronic acids and amines were converted to the corresponding N-arylazoles and N-arylamines, demonstrating the versatality of the reaction.

Key words

copper(I) oxide - N-arylimidazoles - N-arylamines - N-arylation - heterogeneous catalyst

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