An Efficient Chemoselective Synthesis of Pyrido[2,3-d]pyrimidine Derivatives under Microwave Irradiation

Shujiang Tu; Chunmei Li; Feng Shi; Dianxiang Zhou; Qingqing Shao; Longji Cao; Bo Jiang

doi:10.1055/s-2008-1032031

PAPER

An Efficient Chemoselective Synthesis of Pyrido[2,3-d]pyrimidine Derivatives under Microwave Irradiation

Shujiang Tu*, Chunmei Li, Feng Shi, Dianxiang Zhou, Qingqing Shao, Longji Cao, Bo Jiang
School of Chemistry and Chemical Engineering, Key Laboratory of Biotechnology for Medicinal Plant, Xuzhou Normal University, Xuzhou, Jiangsu 221116, P. R. of China
Fax: +86(516)83500065; e-Mail: laotu@xznu.edu.cn;

Abstract

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Abstract

A facile and selective synthesis of poly-substituted pyrido[2,3-d]pyrimidines is accomplished via microwave-assisted multicomponent reactions controlled by the nature of solvent. In addition, a possible mechanism accounting for the reaction is proposed.

Key words

solvent-dependent chemoselectivity - pyrido[2,3-d]pyrimidines - microwave irradiation - heterocycles - multicomponent reaction

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References

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