Synthesis 2008(8): 1316-1318  
DOI: 10.1055/s-2008-1032016
© Georg Thieme Verlag Stuttgart · New York

Synthesis of 4-Maleimidobutyric Acid and Related Maleimides

Renata Marcia de Figueiredoa, Philipp Oczipkaa, Roland Fröhlichb, Mathias Christmann*a
a Institute of Organic Chemistry, RWTH Aachen, Landoltweg 1, 52074 Aachen, Germany
b Institute of Organic Chemistry, University of Münster, Corrensstraße 40, 48149 Münster, Germany
Fax: +49(241)8092127; e-Mail: [email protected];
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Received 12 September 2007
10. Januar 2008 (online)


Maleimidoalkanoic acids and their activated derivatives, such as their N-hydroxysuccinimide esters, are important, though expensive, linkers for the conjugation of biomolecules. During our synthesis of UCS1025A, we have developed a chromatography-free preparation of 4-maleimidobutyric acid on a one-mole scale.


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