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Am J Perinatol 1988; 5(2): 144-145
DOI: 10.1055/s-2007-999674
ORIGINAL ARTICLE

© 1988 by Thieme Medical Publishers, Inc.

Urinary C-Peptide in the Neonate Correlates Both to Maternal Glucose Tolerance and to Fetal Size at Birth

N-O. Lunell, B. Persson, L. V. Devarajan, S. Hassan, H. Hathout, R. Kasrawi, A. Saleh, L. Viktorin
  • Departments of Obstetrics and Gynecology, Huddinge University Hospital, Karolinska Institutet, Stockholm; Medical Faculty, Kuwait University, Kuwait; Department of Pediatrics, St Göran's University Hospital, Karolinska Institutet, Stockholm, Sweden
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Publication Date:
04 March 2008 (online)

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ABSTRACT

In 18 women with gestational diabetes the variables of an oral glucose tolerance test (fasting and 2-hour blood glucose values and area under the blood glucose curve) performed in the last trimester of pregnancy correlated significantly with the urinary C-peptide excretion during the first 12 hours of the life (r = 0.47, 0.71, and 0.60, respectively). In a combined group with 28 type II pregnant diabetic women there was also a significant correlation between the urinary C-peptide excretion of the infants and their skinfold. Assay of the urinary C-peptide excretion of the neonate, reflecting its insulin production, seems to be a sensitive parameter to study the influence of the maternal carbohydrate metabolism in the offspring.

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