Effect of Thirsting on the Biological Half-Life and Organ-Distribution of 3H-Lysin Vasopressin

F. A. László; É Nagy; L. Gáspár; G. Kéri; I. Teplán

doi:10.1055/s-2007-999175

Hormone and Metabolic Research, Inhaltsverzeichnis

Horm Metab Res 1980; 12(9): 471-475
DOI: 10.1055/s-2007-999175

Effect of Thirsting on the Biological Half-Life and Organ-Distribution of ³H-Lysin Vasopressin

F. A. László, É. Nagy, L. Gáspár, G. Kéri, I. Teplán

Endocrine Unit and Research Laboratory, First Department of Medicine, University Medical School, Szeged and First Department of Chemistry and Biochemistry Semmelweis Medical University, Budapest, Hungary

Abstract

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Summary

The biological half-life and organ-distribution of radiochemically pure, biologically active ³H-lysin vasopressin were determined in normally hydrated and in thirsting rats. Three-day thirsting did not vary the biological half-life of the ³H-LVP. The highest ³H-LVP uptake was observed in the neurohypophysis and adenohypophysis of the normally hydrated rats. As a result of thirsting, the accumulation of labelled vasopressin was increased in the neurohypophysis. The results permit the conclusion that the uptake of vasopressin by the neurohypophysis of rat is enhanced at the time of exocytosis and microvesicle formation induced by dehydration.

Key-Words

³ H-Lysin Vasopressin - Thirsting - Biological Half-Life - Organ Distribution

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