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Horm Metab Res 1980; 12(6): 269-273
DOI: 10.1055/s-2007-996264
ORIGINALS

© Georg Thieme Verlag, Stuttgart · New York

Tumoral Calcinosis. Observations during Six Years

E. Leicht, H.-J. Tkocz, H. Seeliger, T. Lauffenburger, H. G. Haas
  • Medizinische Universitätsklinik und Poliklinik, Abteilung für Radiologie und Abteilung für Pathologie, Saarland Universität, Homburg/Saar, Germany, Metabolic Unit, Department of Internal Medicine of the University, Kantonspital Basle, Switzerland
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Publication History

1978

1979

Publication Date:
14 March 2008 (online)

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Summary

Findings of a 56 year old woman suffering from tumoral calcinosis, who was treated for 6 years, are presented. Under conditions known to lead to negative calcium-phosphorus balance, a reduction in tumor size was seen. Transient hypercalcemia was attributed to immobilization. The process of tumor reduction was not definitely accelerated by treatment with ethane-hydroxy-diphosphonate (EHDP; 500 mg/day for 20 months). Nephrotic syndrome as a consequence of amyloidosis developed. Amyloidosis seems to have resulted from the aseptic histiocytic inflammatory process in the tumors. The possible importance of high cholesterol in very low density lipoproteins in the serum of the patient is discussed.

Key-Words

Tumoral Calcinosis - Hyperphosphatemia - Arteriosclerosis - Lipid Metabolism - Very Low Density Lipoproteins - Amyloidosis

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