Findings of a 56 year old woman suffering from tumoral calcinosis, who was treated
for 6 years, are presented. Under conditions known to lead to negative calcium-phosphorus
balance, a reduction in tumor size was seen. Transient hypercalcemia was attributed
to immobilization. The process of tumor reduction was not definitely accelerated by
treatment with ethane-hydroxy-diphosphonate (EHDP; 500 mg/day for 20 months). Nephrotic
syndrome as a consequence of amyloidosis developed. Amyloidosis seems to have resulted
from the aseptic histiocytic inflammatory process in the tumors. The possible importance
of high cholesterol in very low density lipoproteins in the serum of the patient is
discussed.
Tumoral Calcinosis
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Hyperphosphatemia
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Arteriosclerosis
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Lipid Metabolism
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Very Low Density Lipoproteins
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Amyloidosis
