Horm Metab Res 1980; 12(6): 251-256
DOI: 10.1055/s-2007-996260

© Georg Thieme Verlag, Stuttgart · New York

Effect of Somatomedin A and Insulin on Cyclic AMP Generation in Isolated Rat Hepatocytes

Rosa Zederman, Carin Grebing, Kerstin Hall, H. Löw
  • Department of Endocrinology, Karolinska Sjukhuset, Stockholm, Sweden
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Publication History



Publication Date:
14 March 2008 (online)


Insulin and somatomedin A were shown to have inhibitory action on glucagon stimulated but not basal cyclic AMP production in isolated rat hepatocytes. The inhibition was dose-dependent and the potency per mol was about 100 fold higher for insulin than for somatomedin A.