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Horm Metab Res 1980; 12(6): 247-251
DOI: 10.1055/s-2007-996259
DOI: 10.1055/s-2007-996259
ORIGINALS
© Georg Thieme Verlag, Stuttgart · New York
Effect of Streptozotocin Diabetes on Sialic Acid Content and Glycoprotein Binding of Isolated Hepatocytes
Further Information
Publication History
1979
1979
Publication Date:
14 March 2008 (online)
Summary
The possible correlation between sialic acid content of hepatocyte plasma membranes, and their binding capacity was investigated. For that purpose, |3H| asialotransferrin binding was tested with hepatocytes from both normal and streptozotocin treated rats. The observed decrease in binding capacity was parallel to a decrease in the sialic acid content. Insulin therapy restored simultaneously normal blood glucose level, hepatic membrane sialic acid content and binding capacity.
Key-Words
Sialic Acid - Hepatocyte Asialoglycoprotein - Streptozotocin Diabetes