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Horm Metab Res 1980; 12(6): 243-246
DOI: 10.1055/s-2007-996258
DOI: 10.1055/s-2007-996258
ORIGINALS
© Georg Thieme Verlag, Stuttgart · New York
Glucagon Suppressed Proliferation Rate of Mammary Aplastic Carcinoma in Mice
Further Information
Publication History
1979
1979
Publication Date:
14 March 2008 (online)
Summary
Glucagon injected into mice with mammary aplastic carcinoma retards the growth and prolongs the mean survival time of the animals. Glucagon stimulates the plaque-forming capacity and phagocytosis in tumor-bearing animals. Cyclophosphamide treatment abolishes the antitumor effect of glucagon, while the effect of the hormone is enhanced in Corynebacterium parvum pretreated animals. It follows that the tumor-retarding effects of glucagon are mediated mainly by maintaining high B-type reactivity and phagocytosis.
Key-Words
Glucagon - Mammary Aplastic Carcinoma - Immunostimulation