© Georg Thieme Verlag, Stuttgart · New York
Glucagon Suppressed Proliferation Rate of Mammary Aplastic Carcinoma in Mice
10 3 1979
14 March 2008 (online)
Glucagon injected into mice with mammary aplastic carcinoma retards the growth and prolongs the mean survival time of the animals. Glucagon stimulates the plaque-forming capacity and phagocytosis in tumor-bearing animals. Cyclophosphamide treatment abolishes the antitumor effect of glucagon, while the effect of the hormone is enhanced in Corynebacterium parvum pretreated animals. It follows that the tumor-retarding effects of glucagon are mediated mainly by maintaining high B-type reactivity and phagocytosis.
Glucagon - Mammary Aplastic Carcinoma - Immunostimulation