Horm Metab Res 1980; 12(6): 243-246
DOI: 10.1055/s-2007-996258
ORIGINALS

© Georg Thieme Verlag, Stuttgart · New York

Glucagon Suppressed Proliferation Rate of Mammary Aplastic Carcinoma in Mice

K. Pavelić, Jasminka Pavelić
  • Ruder Bošković Institute, Zagreb, Yugoslavia
Further Information

Publication History

7 10 1979

10 3 1979

Publication Date:
14 March 2008 (online)

Summary

Glucagon injected into mice with mammary aplastic carcinoma retards the growth and prolongs the mean survival time of the animals. Glucagon stimulates the plaque-forming capacity and phagocytosis in tumor-bearing animals. Cyclophosphamide treatment abolishes the antitumor effect of glucagon, while the effect of the hormone is enhanced in Corynebacterium parvum pretreated animals. It follows that the tumor-retarding effects of glucagon are mediated mainly by maintaining high B-type reactivity and phagocytosis.