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© Georg Thieme Verlag, Stuttgart · New York
Glucagon Suppressed Proliferation Rate of Mammary Aplastic Carcinoma in Mice
14 March 2008 (online)
Glucagon injected into mice with mammary aplastic carcinoma retards the growth and prolongs the mean survival time of the animals. Glucagon stimulates the plaque-forming capacity and phagocytosis in tumor-bearing animals. Cyclophosphamide treatment abolishes the antitumor effect of glucagon, while the effect of the hormone is enhanced in Corynebacterium parvum pretreated animals. It follows that the tumor-retarding effects of glucagon are mediated mainly by maintaining high B-type reactivity and phagocytosis.
Glucagon - Mammary Aplastic Carcinoma - Immunostimulation