Horm Metab Res 1980; 12(6): 229-230
DOI: 10.1055/s-2007-996253

© Georg Thieme Verlag, Stuttgart · New York

C-Peptide Uptake and Excretion by the Liver in Man

B. Canivet, B. P. Krebs
  • Department of Radioimmunology, Centre Antoine-Lacassagne, Nice, France
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Publication History



Publication Date:
14 March 2008 (online)


The hepatic uptake of C-peptide is believed to be negligeable; this, however, is based on indirect evidence.

In the present work, C-peptide was measured in four non obese non diabetic men simultaneously in portal blood and bile. Small amounts of C-peptide were found in bile, compared with portal levels; these data are consistent with a minor role of the liver in C-peptide metabolism but represent a direct demonstration of an extraction of the peptide by the liver in man.