Endoscopy 2008; 40(5): 422-427
DOI: 10.1055/s-2007-995430
Original article

© Georg Thieme Verlag KG Stuttgart · New York

Colonoscopy results of a French regional FOBT-based colorectal cancer screening program with high compliance

S.  Manfredi1, 2 , C.  Piette2 , G.  Durand2 , G.  Plihon2, 3 , G.  Mallard2 , J.-F.  Bretagne1, 2
  • 1Service des Maladies de l’Appareil Digestif, Hôpital Pontchaillou, Rennes, France
  • 2ADECI 35, Association des dépistages des cancers en Ille-et-Vilaine, Rennes, France
  • 3Cabinet de Gastroentérologie, Rennes, France
Weitere Informationen

Publikationsverlauf

submitted 13 December 2006

accepted after revision 16 November 2007

Publikationsdatum:
29. Januar 2008 (online)

Preview

Background and study aims: Mass screening for colorectal cancer in France was initiated in pilot regions on the basis of the fecal occult blood test (FOBT) followed by colonoscopy in positive cases. We report the colonoscopy results in one of the first areas to be screened (Ille et Vilaine). Patients and methods: Of the total regional population of 908 449, 187 342 of the 213 635 potential screening candidates who were aged 50 - 74 years were invited for FOBT. Of the 51.3 % compliant individuals, 2.6 % were positive, and of these 90.7 % agreed to undergo colonoscopy (n = 2246). The colonoscopy procedure details, findings, and complications were recorded. Subjects were classified according to the most advanced lesion. Positive predictive values of FOBT were calculated according to sex and age. Results: Colonoscopy was complete in 96.3 % of cases. Only 23 adverse events were encountered (1.02 %). Colorectal cancer was diagnosed in 237 cases (10.6 %, 78.4 % of which were clinical stages I - II). The rates of overall adenomas and advanced adenomas were 33.1 % and 21.6 %, respectively. The risk of cancer and advanced adenoma increased significantly in men and in older people. Conclusion: The results of mass screening with FOBT followed by colonoscopy in this population-based study are very encouraging in terms of compliance, early findings, and complications. Extension of this program to the whole of France is justified.

References

S. Manfredi PhD 

Service des Maladies de l’Appareil Digestif
Hôpital Pontchaillou

35033 Rennes
France

Fax: +33-2-99284189

eMail: sylvain.manfredi@chu-rennes.fr