Planta Med 2007; 73(15): 1596-1599
DOI: 10.1055/s-2007-993747
Natural Product Chemistry
Letter
© Georg Thieme Verlag KG Stuttgart · New York

Antibacterial Lignans and Triterpenoids from Rostellularia procumbens

Yongli Zhang1 , 2 , Fukai Bao3 , Juanjuan Hu4 , Shengwang Liang2 , Yu Zhang3 , Guanhua Du4 , Caijun Zhang3 , Yongxian Cheng1
  • 1State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, P. R. China
  • 2Faculty of Analytical Chemistry, Henan College of Traditional Chinese Medicine, Zhengzhou, P. R. China
  • 3Department of Microbiology and Immunology, Kunming Medical College, Kunming, P. R. China
  • 4Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing, P. R. China
Further Information

Publication History

Received: February 13, 2007 Revised: September 11, 2007

Accepted: October 17, 2007

Publication Date:
03 December 2007 (online)

Abstract

One new lignan, rostellulin A (1), four known lignans, justin B (2), justicidin C (3), cilinaphthalide A (4), and justicidin A (5), and four known triterpenoids, ursolic acid (6), euscaphic acid (7), 2α-hydroxyursolic acid (8), and tormentic acid (9), have been isolated from the whole plants of Rostellularia procumbens. Their structures were established on the basis of spectral data, including extensive NMR experiments. To our knowledge, compounds 6 - 9 are known compounds but not previously isolated from R. procumbens, 4 was previously reported from other Rostellularia species. Antibacterial activities of 1 - 9 were evaluated against eight bacterial strains with the agar dilution method, and they were found to possess antimicrobial activity with MIC values in the range of 1.56 - 100 μg/mL. None of the lignans exhibited cytotoxic activity against HCT-8 and Bel-7402 cells at concentrations up to 5 μg/mL.

References

Dr. Yongxian Cheng

State Key Laboratory of Phytochemistry and Plant Resources in West China

Kunming Institute of Botany

Chinese Academy of Sciences

Kunming 650204

People’s Republic of China

Phone: +86-871-522-3048

Fax: +86-871-522-3048

Email: [email protected]