Exp Clin Endocrinol Diabetes 2008; 116(4): 241-245
DOI: 10.1055/s-2007-993165

© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

IgG Antibodies Against Food Antigens are Correlated with Inflammation and Intima Media Thickness in Obese Juveniles

M. Wilders-Truschnig 1 , H. Mangge 1 , C. Lieners 2 , H-. J. Gruber 1 , C. Mayer 1 , W. März 1
  • 1Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University Graz, Austria
  • 2Laboratoires Réunis Junglinster, Luxembourg
Further Information

Publication History

received 28.08.2007 first decision 11.10.2007

accepted 26.10.2007

Publication Date:
10 December 2007 (online)


Objective: Systemic low grade inflammation may contribute to the development of obesity, insulin resistance, diabetes mellitus and atherosclerotic vascular disease. Food intolerance reflected by immunoglobulin G (IgG) antibodies may predispose to low grade inflammation and atherogenesis. We examined the relationship between IgG antibodies specific for food components, low grade inflammation and early atherosclerotic lesions in obese and normal weight juveniles.

Research Methods and Procedures: We determined IgG antibodies directed against food antigens, C-reactive protein (CRP) and the thickness of the intima media layer (IMT) of the carotid arteries in 30 obese children and in 30 normal weight children.

Results: Obese juveniles showed a highly significant increase in IMT (p=0.0001), elevated CRP values (p=0.0001) and anti-food IgG antibody concentrations (p=0.0001) compared to normal weight juveniles. Anti-food IgG showed tight correlations with CRP (p=0.001/r=0.546) and IMT (p=0.0001/r=0.513) and sustained highly significant in a multiple regression model.

Discussion: We show here, that obese children have significantly higher IgG antibody values directed against food antigens than normal weight children. Anti- food IgG antibodies are tightly associated with low grade systemic inflammation and with the IMT of the common carotid arteries. These findings raise the possibility, that anti-food IgG is pathogenetically involved in the development of obesity and atherosclerosis.


  • 1 Bastard JP, Maachi M, Lagathu C. et al . Recent advances in the relationship between obesity, inflammation and insulin resistance.  Eur Cytokine Netw. 2006;  17 4-12
  • 2 Paoletti R, Bolego C, Poli A, Cignarella A. Metabolic syndrome, inflammation and atherosclerosis.  Vasc Health Risk Manag. 2006;  2 145-152
  • 3 Shoelson SE, Herrero L, Naaz A. Obesity, inflammation, and insulin resistance.  Gastroenterology. 2007;  132 2169-2180
  • 4 Cook DG, Mendall MA, Whincup PH. et al . C-reactive protein concentration in children: relationship to adiposity and other cardiovascular risk factors.  Atherosclerosis. 2000;  149 139-150
  • 5 Engstrom G, Hedblad B, Stavenow L. et al . Inflammation-sensitive plasma proteins are associated with future weight gain.  Diabetes. 2003;  52 2097-2101
  • 6 Festa A, D'Agostino  Jr  R, Howard G. et al . Chronic subclinical inflammation as part of the insulin resistance syndrome: the Insulin Resistance Atherosclerosis Study (IRAS).  Circulation. 2000;  102 42-47
  • 7 Freeman DJ, Norrie J, Caslake MJ. et al . C-reactive protein is an independent predictor of risk for the development of diabetes in the West of Scotland Coronary Prevention Study.  Diabetes. 2002;  51 1596-1600
  • 8 Tchernof A, Nolan A, Sites CK, Ades PA, Poehlman ET. Weight loss reduces C-reactive protein levels in obese postmenopausal women.  Circulation. 2002;  105 564-569
  • 9 Ziccardi P, Nappo F, Giugliano G. et al . Reduction of inflammatory cytokine concentrations and improvement of endothelial functions in obese women after weight loss over one year.  Circulation. 2002;  105 804-809
  • 10 Mangge H, Schauenstein K, Stroedter L. et al . Low grade inflammation in juvenile obesity and type 1 diabetes associated with early signs of atherosclerosis.  Exp Clin Endocrinol Diabetes. 2004;  112 378-382
  • 11 Giannini C, Giorgis T de, Scarinci A. et al . Obese related effects of inflammatory markers and insulin resistance on increased carotid intima media thickness in pre-pubertal children.  Atherosclerosis. 2007; 
  • 12 Jarvisalo MJ, Jartti L, Nanto-Salonen K. et al . Increased aortic intima-media thickness: a marker of preclinical atherosclerosis in high-risk children.  Circulation. 2001;  104 2943-2947
  • 13 Raitakari OT, Juonala M, Kahonen M. et al . Cardiovascular risk factors in childhood and carotid artery intima-media thickness in adulthood: the Cardiovascular Risk in Young Finns Study.  Jama. 2003;  290 2277-2283
  • 14 Ridker PM. Clinical application of C-reactive protein for cardiovascular disease detection and prevention.  Circulation. 2003;  107 363-369
  • 15 Isolauri E, Rautava S, Kalliomaki M. Food allergy in irritable bowel syndrome: new facts and old fallacies.  Gut. 2004;  53 1391-1393
  • 16 Atkinson W, Sheldon TA, Shaath N, Whorwell PJ. Food elimination based on IgG antibodies in irritable bowel syndrome: a randomised controlledtrial.  Gut. 2004;  53 1459-1464
  • 17 Shanahan F, Whorwell PJ. IgG-mediated food intolerance in irritable bowel syndrome: a real phenomenon or an epiphenomenon?.  Am J Gastroenterol. 2005;  100 1558-1559
  • 18 Mawdsley JE, Irving P, Makins R. IgG antibodies to foods in IBS.  Gut. 2005;  54 567
  • 19 Zar S, Benson MJ, Kumar D. Food-specific serum IgG4 and IgE titers to common food antigens in irritable bowel syndrome.  Am J Gastroenterol. 2005;  100 1550-1557
  • 20 Zar S, Kumar D, Benson MJ. Food hypersensitivity and irritable bowel syndrome.  Aliment Pharmacol Ther. 2001;  15 439-449
  • 21 Wanner C, Horl WH, Luley CH, Wieland H. Effects of HMG-CoA reductase inhibitors in hypercholesterolemic patients on hemodialysis.  Kidney Int. 1991;  39 754-760
  • 22 Paoletti R, Poli A, Cignarella A. The emerging link between nutrition, inflammation and atherosclerosis.  Expert Rev Cardiovasc Ther. 2006;  4 385-393
  • 23 Barnes RM. IgG and IgA antibodies to dietary antigens in food allergy and intolerance.  Clin Exp Allergy. 1995;  25 ((Suppl 1)) 7-9
  • 24 Sewell WA. IgG food antibodies should be studied in similarly treated groups.  Gut. 2005;  54 566
  • 25 Teuber SS, Porch-Curren C. Unproved diagnostic and therapeutic approaches to food allergy and intolerance.  Curr Opin Allergy Clin Immunol. 2003;  3 217-221
  • 26 Pradhan AD, Manson JE, Rifai N, Buring JE, Ridker PM. C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus.  Jama. 2001;  286 327-334
  • 27 Visser M, Bouter LM, McQuillan GM, Wener MH, Harris TB. Elevated C-reactive protein levels in overweight and obese adults.  Jama. 1999;  282 2131-2135
  • 28 Yudkin JS, Kumari M, Humphries SE, Mohamed-Ali V. Inflammation, obesity, stress and coronary heart disease: is interleukin-6 the link?.  Atherosclerosis. 2000;  148 209-214
  • 29 Torzewski J, Torzewski M, Bowyer DE. et al . C-reactive protein frequently colocalizes with the terminal complement complex in the intima of early atherosclerotic lesions of human coronary arteries.  Arterioscler Thromb Vasc Biol. 1998;  18 1386-1392
  • 30 Griselli M, Herbert J, Hutchinson WL. et al . C-reactive protein and complement are important mediators of tissue damage in acute myocardial infarction.  J Exp Med. 1999;  190 1733-1740
  • 31 Pasceri V, Willerson JT, Yeh ET. Direct proinflammatory effect of C-reactive protein on human endothelial cells.  Circulation. 2000;  102 2165-2168
  • 32 Zwaka TP, Hombach V, Torzewski J. C-reactive protein-mediated low density lipoprotein uptake by macrophages: implications for atherosclerosis.  Circulation. 2001;  103 1194-1197
  • 33 Chambless LE, Heiss G, Folsom AR. et al . Association of coronary heart disease incidence with carotid arterial wall thickness and major risk factors: the Atherosclerosis Risk in Communities (ARIC) Study, 1987-1993.  Am J Epidemiol. 1997;  146 483-494
  • 34 Hodis HN, Mack WJ, Bree L La. et al . The role of carotid arterial intima-media thickness in predicting clinical coronary events.  Ann Intern Med. 1998;  128 262-269


Dr. M. Wilders-Truschnig

Clinical Institute of Medical and Chemical Laboratory Diagnostics

Medical University Graz

Auenbruggerplatz 15

8036 Graz


Phone: +43/316/385 33 41

Fax: +43/316/385 34 30

Email: martie.truschnig@klinikum-graz.at