Synlett 2008(1): 37-40  
DOI: 10.1055/s-2007-992379
© Georg Thieme Verlag Stuttgart · New York

A New Reagent System for Efficient Silylation of Alcohols: Silyl Chloride-N-Methylimidazole-Iodine

Agnieszka Bartoszewicza, Marcin Kaleka, Johan Nilssona, Renata Hiresovaa, Jacek Stawinski*a,b
a Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, 10691 Stockholm, Sweden
b Institute of Bioorganic Chemistry, Polish Academy of Sciences, Noskowskiego 12/14, 61704 Poznan, Poland
Further Information

Publication History

Received 18 September 2007
Publication Date:
21 November 2007 (eFirst)


It was found that reactions of alcohols with silyl chlorides in the presence of N-methylimidazole were significantly accelerated by the added iodine, and on this basis a general, and high yielding method for efficient silylation of primary, secondary, and tertiary alcohols was developed.