Zeitschrift für Phytotherapie 2007; 28(5): 223-229
DOI: 10.1055/s-2007-992166
ZPT | Forschung

© Sonntag Verlag in MVS Medizinverlage Stuttgart GmbH & Co. KG

Aktuelle Inhaltstoffe aus höheren Pilzen in der wissenschaftlichen Forschung zu Immunsystem und Stoffwechsel (2)[*]

Ekkehard Busch1 , Reimund Wantoch von Rekowski1 , Helga Mölleken2
  • 1 Mykomax GmbH, Wuppertal
  • 2 Bergische Universität, FB C, Botanik - Physiologische Chemie der Pflanzen
Further Information

Publication History

Publication Date:
18 June 2008 (online)

Zusammenfassung

Aktuell sind ca. 200 verschiedene Pilzarten weltweit von medizinischem Interesse, deren präventive oder heilungsunterstützende Eigenschaften wissenschaftlich untersucht werden. Das medizinische Spektrum umfasst neben den immunstimulierenden und antikanzerogenen Wirkungen auch die positiven Einflüsse auf den Lipidstoffwechsel. Hericium erinaceus, Agaricus blazei, Auricularia auricula-judae gehören zu den essbaren höheren Pilzen, die durch ihre Inhaltstoffe - primär Makromoleküle, wie Polysaccharide und Proteoglucane - in der medizinischen Forschung neben zahlreichen anderen Pilzextrakten großes Interesse gefunden haben.

Summary

The effect of mushrooms substances on the immune system and body metabolism: Current state of scientific research

Worldwide, based on scientific investigation with regard to preventive or healing characteristics, there are currently about 200 different types of mushrooms that are medically interesting. Most important are the immune stimulating, tumour preventing and anticancerous effects of different biopolymers like polysaccharides and proteoglycanes as well as their positive role in lipid and cardiovascular metabolisms. In this review, we will discuss Hericium erinaceus, Agaricus blazei and Auricularia auriculajudae with various proteoglycanes and other substances that are of medical interest, and are primarily used in Asia.

1 Teil 1: Z Phytotherapie 2007; 28 (3): 115-124.

Literatur

  • 1 Ahn WS, Kim DJ, Chae GT, Lee JM, et al.. Natural killer cell activity and quality of life were improved by consumption of a mushroom extract, Agaricus blazei Murill Kyowa, in gynecological cancer patients undergoing chemotherapy.  Int J Gynecol Cancer. 2004;  14 589-594
  • 2 Angeli JP, Ribeiro LR, Gonzaga ML, et al.. Protective effects of beta-glucan extracted from Agaricus brasiliensis against chemically induced DNA damage in human lymphocytes.  Cell Biol Toxicol. 2006;  22 285-291
  • 3 Barbisan LF, Scolastici C, Miyamoto M, et al.. Effects of crude extracts of Agaricus blazei on DNA damage and on rat liver carcinogenesis induced by diethylnitrosamine.  Genet Mol Res. 2003;  2 295-308
  • 4 Bernardshaw S, Lyberg T, Hetland G, Johnson E. Effect of an extract of the mushroom Agaricus blazei Murill on expression of adhesion molecules and production of reactive oxygen species in monocytes and granulocytes in human whole blood ex vivo.  Acta Patho Microbiol Immunol Scandinavica (APMIS). 2007;  115 719-725
  • 5 Cheung PC. Hypocholesterolemic effect of two edible mushrooms: Auricularia auricula (tree-ear) and Tremella fuciformis (white jelly-leaf) in hypercholesterolemic rats.  Nutr Res. 1996;  16 1721-1725
  • 6 Dong O, Jia LM, Fang JN. A beta D-glucan isolated from the fruiting bodies of Hericium erinaceus and the aqueous conformation.  Carbohydr Res. 2006;  341 791-795
  • 7 Ellertsen LK, Hetland G, Johnson E, Grinde B. Effect of a medicinal extract from Agaricus blazei Murill on gene expression in a human momocyte cell line as examined by microarrays and immuno assays.  Int Immunopharmacol. 2006;  6 133-143
  • 8 Fujimiya Y, Suzuki Y, Oshiman K, et al.. Selective tumoricidal effect of soluble proteoglucan extracted from the basidiomycete, Agaricus blazei Murill, mediated via natural killer cell activation and apoptosis.  Cancer Immunol Immunother. 1998;  46 147-159
  • 9 Hsu CH, Liao YL, Lin SC, Hwang KC, Chou P. The mushroom Agaricus blazei Murill in combination with metformin and gliclazide improves insulin resistance in type 2 diabetes: a randomized, double-blinded, and placebocontrolled clinical trial.  J Altern Complemt Med. 2007;  13 97-102
  • 10 Jeong SC, Cho SP, Yang BK, Gu YA, et al.. Production of an anti-complement exo-polymer produced by Auricularia auricula-judae in submerged culture.  Biotechnol Lett. 2004;  26 923-927
  • 11 Jia LM, Liu L, Dong Q, Fang JN. Structural investigations of a novel thamnoglucogalactan isolated from the fruiting bodies of the fungus Hericium erinaceus .  Carbohydr Res. 2004;  339 2667-2671
  • 12 Jin CY, Choi YH, Moon DO, Park C, et al.. Induction of G2/M arrest and apoptosis in human gastric epithelial AGS cells by aqueous extract of Agarius balzei .  Oncol Rep. 2006;  16 1349-1355
  • 13 Kasai H, He LM, Kawamura M, Yang PT, et al.. IL-12 production induced by Agaricus blazei fraction H (ABH) involves toll-like receptor (TLR).  Evid Based Complement Alternat Med. 2004;  1 259-267
  • 14 Kawamura M, Kasai H. Delayed cell cycle progression and apoptosis induced by hemicellulase-treated Agaricus blazei .  Evid Based Complement Alternat Med. 2007;  4 83-94
  • 15 Kawamura M, Kasai H, He L, Deng X, et al.. Antithetical effects of hemicellulase-treated Agaricus blazei on the maturation of murine bone-marrow-derived dendritic cells.  Immunol. 2005;  114 397-409
  • 16 Kim GY, Lee MY, Lee HJ, Moon DO, et al.. Effect of water-soluble proteoglycan isolated from Agaricus blazei on the maturation of murine bone marrow-derived dendritic cells.  Int Immunopharmacol. 2005;  5 1523-1532
  • 17 Kim YW, Kim KH, Choi HJ, Lee DS. Anti-diabetic activity of beta-glucans and their enzymatically hydrolyzed oligosaccharides from Agaricus blazei .  Biotechnol Lett. 2005;  27 483-487
  • 18 Kobayashi H, Yoshida R, Kanada Y, Fukuda Y, et al.. Suppressing effects of daily oral supplementation of beta-glucan extracted from Agaricus blazei Murill on and peritoneal disseminated metastasis in mouse model.  J Cancer Res Clin Onc. 2005;  131 527-538
  • 19 Lindequist U, Niedermeyer TH, Jülich WD. The pharmacological potential of mushrooms (Review).  Evid Based Complement Alternat Med. 2005;  2 285-299
  • 20 Mizuno M, Morimoto M, Minato K, Tsuchida H. Polysaccharides from Agaricus blazei stimulate lymphocyte T-cell subsets in mice.  Biotechnol Biochem. 1998;  62 434-437
  • 21 Takeuchi H, He P, Mooi LY. Reductive effect of hot-water extracts from woody ear (Auricularia auricula-judae Quel.) on food intake and blood glucose concentration in genetically diabetic KK-Ay mice.  J Nutr Science Vitaminol. 2004;  50 300-304
  • 22 Ukai S, Kiho T, Hara C, Morita M, et al.. Polysaccharides in fungi: XIII. Antitumor activity of various polysaccharides isolated from Dictyophora indusiata, Ganoderma japonicum, Cordyceps cicadae, Auricularia auriculajudae and Auricularia sp.  Pharma Bull (Tokyo). 1983;  31 741-744
  • 23 Wang J, Cheng RZ, Wang JZ. Clinical observation on treatment of gastro-intestinal cancer with Agaricus blazei .  Gansu Med Journal. 1994;  13 5-7
  • 24 Wasser SP. Medicinal mushrooms as a source of antitumor and immunomodulating polysaccharides.  Appl Microbiol Biotechnol. 2002;  60 258-274
  • 25 Xu HM, Xie ZH, Zhang WY. Immunomodulatory function of polysaccharide of Hericium erinaceus .  Chinese J Int Trad Western Med. 1994;  14 427-428
  • 26 Yang BK, Park JB, Song CH. Hypolipidemic effect of an exo-biopolymer produced from a submerged mycelial culture of Hericium erinaceus .  Biosci Biotechnol Biochem. 2003;  67 1292-1298
  • 27 Yang YJ, Jiang RZ, Chen YH. Study on chemical composition of Hericium erinaceus HEP-2.  Nat Prod Res Develop. 2004;  16 194-197
  • 28 Yuan Z, He P, Takeuchi H. Ameliorating effects of water-soluble polysaccharides from woody ear (Auricularia auricula-judae Quel.) in genetically diabetic KK-Ay mice.  J Nutr Sci Vitaminol. 1998;  44 829-840
  • 29 Yuminamochi E, Koike T, Takeda K, Horiuchi I, Okumura K. Interleukin-12- and interferon-gamma-mediated natural killer cell activation by Agaricus blazei Murill.  Immunol. 2007;  121 197-206
  • 30 Hobbs C. Medicinal Mushrooms: an Exploration of Tradition, Healing, and Culture. Botanica Press, Santa Cruz, CA 1996
  • 31 .. http://www.Naturheilkundelexikon.de (C) MZ-Verlag Ltd. 2005

1 Teil 1: Z Phytotherapie 2007; 28 (3): 115-124.

Dr. Helga Mölleken

Bergische Universität Wuppertal

Fachbereich C

Botanik - Physiologische Chemie der Pflanzen

Gaußstr. 20

42119 Wuppertal

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